The role of extracellular vesicles in prostate cancer with clinical applications

Yu Ling Tai, Chun Jung Lin, Tsai Kun Li, Tang Long Shen, Jer Tsong Hsieh, Benjamin P.C. Chen

Research output: Contribution to journalReview article

Abstract

In mammalian cells, extracellular vesicles (EVs) derived from the endosomal system carry many different kinds of bioactive molecule to deliver to recipient cells in a paracrine or endocrine manner. EVs can mediate local and systemic intercellular communications, including reeducating stromal cells, remodeling the architecture of the tumor microenvironment, modulating cancer metabolism and metastases, or even conferring drug resistance. Because the molecular and functional characteristics of prostate cancer (PCa) evolve over time, the bioactive molecule profiles/signatures of tumor-derived EVs (TDEs) reflect the real-time status of cancer cells. TDEs appear to be valuable diagnostic and prognostic biomarkers as well as potential therapeutic vehicles, suggesting their essential role in precision medicine of disease management. We summarized critical aspects of TDEs in PCa and discussed their potential clinical applications.

Original languageEnglish (US)
Pages (from-to)R133-R144
JournalEndocrine-Related Cancer
Volume27
Issue number5
DOIs
StatePublished - May 2020

Keywords

  • Diagnostic biomarker
  • Extracellular vesicles
  • Prognostic biomarker
  • Prostate cancer

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Oncology
  • Endocrinology
  • Cancer Research

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