The role of lipoprotein-associated phospholipase A2 in the metabolic syndrome and diabetes

Hiroshi Noto, Pranav Chitkara, Philip Raskin

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28 Scopus citations

Abstract

Objectives: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a novel inflammation marker. We investigated its association with other coronary risk factors and evaluated its role as a comprehensive marker of the metabolic syndrome in individuals with type 2 diabetes. Methods: Our cross-sectional study evaluated 92 insulin-treated subjects with type 2 diabetes. Biochemical measurements of Lp-PLA2, glycemic control, lipid profiles, and C-reactive protein were carried out. Seventy-seven subjects were diagnosed as having the metabolic syndrome, which was defined according to the American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Results: Lp-PLA2 was significantly correlated with waist-hip ratio (r=.25), triglycerides (r=.50), high-density lipoprotein cholesterol (r=-.31), and low-density lipoprotein cholesterol (LDL-C; r=.27; all P<.02). In a multiple-regression model, triglycerides and LDL-C levels were the significant predictors of Lp-PLA2. Lp-PLA2 was significantly higher in subjects with the metabolic syndrome than in those without it (268±23.4 vs. 127±15.8 ng/ml, P<.001). There was a linear increase in Lp-PLA2 with an increment of the number of the metabolic syndrome criteria (Ptrend=.041). Another multiple-regression model showed that the hypertriglyceridemia component was the only predictor of Lp-PLA2. Conclusions: Our findings suggest that Lp-PLA2 assay potentially facilitates a more comprehensive assessment of the metabolic syndrome in patients with type 2 diabetes on insulin.

Original languageEnglish (US)
Pages (from-to)343-348
Number of pages6
JournalJournal of Diabetes and Its Complications
Volume20
Issue number6
DOIs
StatePublished - Nov 1 2006

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Keywords

  • Inflammation
  • Insulin resistance
  • Lipoprotein-associated phospholipase A (Lp-PLA)
  • Metabolic syndrome
  • Platelet-activating factor-acetylhydrolase (PAF-AH)

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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