The role of lipoproteins in the regulation of progesterone secretion by the human corpus luteum

B. R. Carr, P. C. MacDonald, E. R. Simpson

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Abstract

The results of recent in vitro investigations have suggested a major role of LDL-cholesterol as a factor regulating P biosynthesis by the human CL. The vascularization of the CL allows for a mechanism whereby LDL-cholesterol gains access to the luteinized granulosa cells. The levels of LDL in follicular fluid and in plasma during the luteal phase of normal women support the significance of LDL in the regulation of P in vivo. Finally, the low levels of P and the absence of LDL in plasma in women with abetalipoproteinemia and in the observations of women with poor vascularization of the CL suggest that deficiencies in delivery of LDL to the luteinized granulosa cells during the luteal phase may result in luteal phase dysfunction.

Original languageEnglish (US)
Pages (from-to)303-311
Number of pages9
JournalFertility and sterility
Volume38
Issue number3
StatePublished - Jan 1 1982

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ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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