TY - GEN
T1 - The role of magnetic resonance imaging in prostate cancer imaging and staging
AU - Lenkinski, Robert E.
PY - 2011
Y1 - 2011
N2 - MRI of the prostate can be used to address several of the clinical issues associated with diagnosing and treating prostate cancer. We have found dynamic contrast enhanced MRI (DCEMRI) to be valuable tool in visualizing and characterizing malignancies. Our approach is based on the threetime point method (3TP), which is a simplified model based method for analyzing DCEMRI of the prostate. This method is a high-spatial, low temporal resolution approach. We have found that this approach can be combined with more conventional MRI methods to give highly accurate staging of prostate cancer. An unanticipated clinical benefit has been the ability to use DCEMRI to image men with elevated PSA and repeat negative biopsy. We have also used a model independent approach based on principal component analysis (PCA) to analyze the DCEMRI datasets.
AB - MRI of the prostate can be used to address several of the clinical issues associated with diagnosing and treating prostate cancer. We have found dynamic contrast enhanced MRI (DCEMRI) to be valuable tool in visualizing and characterizing malignancies. Our approach is based on the threetime point method (3TP), which is a simplified model based method for analyzing DCEMRI of the prostate. This method is a high-spatial, low temporal resolution approach. We have found that this approach can be combined with more conventional MRI methods to give highly accurate staging of prostate cancer. An unanticipated clinical benefit has been the ability to use DCEMRI to image men with elevated PSA and repeat negative biopsy. We have also used a model independent approach based on principal component analysis (PCA) to analyze the DCEMRI datasets.
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U2 - 10.1109/ISBI.2011.5872829
DO - 10.1109/ISBI.2011.5872829
M3 - Conference contribution
AN - SCOPUS:80055030859
SN - 9781424441280
T3 - Proceedings - International Symposium on Biomedical Imaging
SP - 2109
EP - 2112
BT - 2011 8th IEEE International Symposium on Biomedical Imaging
T2 - 2011 8th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI'11
Y2 - 30 March 2011 through 2 April 2011
ER -