The role of major histocompatibility complex class I chain-related gene A antibodies in organ transplantation

Yizhou Zou, Peter Stastny

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations

Abstract

PURPOSE OF REVIEW: Major histocompatibility complex class I chain-related gene A (MICA) antigens are expressed on the endothelium, they are polymorphic and have been shown to be recognized by antibodies produced by transplant recipients. Methods for detection of these antibodies have become available. In the 15th International Histocompatibility Workshop, a study for MICA antibody testing and of MICA genotyping was organized. RECENT FINDINGS: Antibodies against MICA antigens have been determined either using cells transfected with MICA alleles or recombinant MICA antigens. MICA epitopes were characterized by empirical study of human sera and by correlation with MICA polymorphic amino acids. Sera were absorbed with cells transfected with MICA alleles and site-directed mutagenesis was employed to analyze complex sera. A number of clinical studies have shown associations of antibodies against MICA with decreased survival of kidney transplants and in one investigation with acute rejection in recipients of heart allografts. SUMMARY: In addition to the HLA antigens, which elicit a strong immune response against allografted organs, the MICA antigens may be recognized as foreign and induce the production of MICA-specific antibodies. Antibodies against MICA have been associated with a decrease in the survival of organ allografts. The results suggest the MICA antigens are transplantation antigens that can induce an immune response associated with graft failure.

Original languageEnglish (US)
Pages (from-to)414-418
Number of pages5
JournalCurrent Opinion in Organ Transplantation
Volume14
Issue number4
DOIs
StatePublished - Aug 1 2009

Keywords

  • HLA
  • Major histocompatibility complex class I chain-related gene A
  • Major histocompatibility complex class I chain-related gene B
  • Sequence-based typing
  • Single antigen Luminex test

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation

Fingerprint Dive into the research topics of 'The role of major histocompatibility complex class I chain-related gene A antibodies in organ transplantation'. Together they form a unique fingerprint.

Cite this