The role of metabolic states in development and disease

Matthew H. Sieber, Allan C. Spradling

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

During development, cells adopt distinct metabolic strategies to support growth, produce energy, and meet the demands of a mature tissue. Some of these metabolic states maintain a constrained program of nutrient utilization, while others providing metabolic flexibility as a means to couple developmental progression with nutrient availability. Here we discuss our understanding of metabolic programs, and how they support specific aspects of animal development. During phases of rapid proliferation a subset of metabolic programs provide the building blocks to support growth. During differentiation, metabolic programs shift to support the unique demands of each tissue. Finally, we discuss how a model system, such as Drosophila egg development, can provide a versatile platform to discover novel mechanisms controlling programmed shift in metabolism.

Original languageEnglish (US)
Pages (from-to)58-68
Number of pages11
JournalCurrent Opinion in Genetics and Development
Volume45
DOIs
StatePublished - Aug 1 2017

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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