The role of myosin phosphorylation in regulating actin-myosin interaction in human blood platelets

R. S. Adelstein, M. A. Conti, B. Barylko

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

The contractile proteins actin and myosin are present in most if not all eukaryotic cells at some time during their life cycle. The presence of these proteins in many different types of cells implies that they play an important role in cellular function. Among the functions that have been attributed to non-muscle actin and mysosin are: mitosis, cytokinesis and in platelets, te release reaction and clot retraction. Our laboratory is interested in understanding the mechanism controlling actin-myosin interaction in platelets, other non-muscle cells and smooth muscle. We have found that one important mechanism of control involves the phosphorylation and dephosphorylation of myosin (Adelstein et al. 1977a). In this article we shall briefly review our findings about this control mechanism in platelets.

Original languageEnglish (US)
Pages (from-to)241-244
Number of pages4
JournalThrombosis and Haemostasis
Volume40
Issue number2
StatePublished - Dec 1 1978

ASJC Scopus subject areas

  • Hematology

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