The role of the transcription factor ets1 in lupus and other autoimmune diseases

Lee Ann Garrett-Sinha, Alyssa Kearly, Anne B. Satterthwaite

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by excess B- and T-cell activation, the development of autoantibodies against self-antigens including nuclear antigens, and immune complex deposition in target organs, which triggers an inflammatory response and tissue damage. The genetic and environmental factors that contribute to the development of SLE have been studied extensively in both humans and mouse models of the disease. One of the important genetic contributions to SLE development is an alteration in the expression of the transcription factor Ets1, which regulates the functional differentiation of lymphocytes. Here, we review the genetic, biochemical, and immunological studies that have linked low levels of Ets1 to aberrant lymphocyte differentiation and to the pathogenesis of SLE.

Original languageEnglish (US)
Pages (from-to)485-509
Number of pages25
JournalCritical Reviews in Immunology
Volume36
Issue number6
DOIs
StatePublished - Jan 1 2016

Fingerprint

Systemic Lupus Erythematosus
Autoimmune Diseases
Transcription Factors
Lymphocytes
Nuclear Antigens
Autoantigens
Antigen-Antibody Complex
Autoantibodies
Molecular Biology
Chronic Disease
T-Lymphocytes

Keywords

  • Autoantibodies
  • B-cell tolerance
  • Ets1
  • Plasma cells
  • Systemic lupus erythematosus
  • T-cell cytokines

ASJC Scopus subject areas

  • Immunology

Cite this

The role of the transcription factor ets1 in lupus and other autoimmune diseases. / Garrett-Sinha, Lee Ann; Kearly, Alyssa; Satterthwaite, Anne B.

In: Critical Reviews in Immunology, Vol. 36, No. 6, 01.01.2016, p. 485-509.

Research output: Contribution to journalReview article

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