The role of the type III secretion system in the intracellular lifestyle of enteric pathogens

Marcela de Souza Santos, Kim Orth

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Many bacterial pathogens have evolved to infect host cells from the inside. In fact, some bacteria, such as Rickettsia spp. and Coxiella spp., are entirely reliant on host intracellular resources to propagate (1). The adaptation of bacteria to an intracellular lifecycle is thought to confer a means to avoid the harsh extracellular milieu (low pH, physical stress, host defenses), to gain access to a nutrient-rich environment, and to facilitate the spread of the pathogen to neighboring host tissues (2, 3).

Original languageEnglish (US)
Title of host publicationBacteria and Intracellularity
Publisherwiley
Pages199-214
Number of pages16
ISBN (Electronic)9781683672791
ISBN (Print)9781683670254
DOIs
StatePublished - Jan 1 2020

Keywords

  • Enteric pathogens
  • Intracellular lifestyle
  • Salmonella enterica serovar typhimurium
  • Salmonella-containing vacuole
  • Shigella flexneri
  • Type III secretion system
  • Vacuole biogenesis
  • Vibrio parahaemolyticus

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

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