The Saccharomyces cerevisiae gene MEC1 represents a structural homolog of the human gene ATM mutated in ataxia telangiectasia patients. Like human ataxia telangiectasia cell lines, mec1 mutants are defective in G2 and S- phase cell cycle checkpoints in response to radiation treatment. Here we show an additional defect in G1 arrest following treatment with UV light or gamma rays and map a defective arrest stage at or upstream of START in the yeast cell cycle.
|Original language||English (US)|
|Number of pages||3|
|Journal||Journal of Bacteriology|
|Publication status||Published - 1996|
ASJC Scopus subject areas
- Applied Microbiology and Biotechnology