The Saccharomyces cerevisiae MEC1 gene, which encodes a homolog of the human ATM gene product, is required for G1 arrest following radiation treatment

Wolfram Siede, James B. Allen, Stephen J. Elledge, Errol C. Friedberg

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The Saccharomyces cerevisiae gene MEC1 represents a structural homolog of the human gene ATM mutated in ataxia telangiectasia patients. Like human ataxia telangiectasia cell lines, mec1 mutants are defective in G2 and S- phase cell cycle checkpoints in response to radiation treatment. Here we show an additional defect in G1 arrest following treatment with UV light or gamma rays and map a defective arrest stage at or upstream of START in the yeast cell cycle.

Original languageEnglish (US)
Pages (from-to)5841-5843
Number of pages3
JournalJournal of Bacteriology
Volume178
Issue number19
StatePublished - 1996

Fingerprint

Ataxia Telangiectasia
Saccharomyces cerevisiae
S Phase Cell Cycle Checkpoints
G2 Phase Cell Cycle Checkpoints
Radiation
Gamma Rays
Ultraviolet Rays
Genes
Cell Cycle
Yeasts
Cell Line
Therapeutics

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Immunology

Cite this

The Saccharomyces cerevisiae MEC1 gene, which encodes a homolog of the human ATM gene product, is required for G1 arrest following radiation treatment. / Siede, Wolfram; Allen, James B.; Elledge, Stephen J.; Friedberg, Errol C.

In: Journal of Bacteriology, Vol. 178, No. 19, 1996, p. 5841-5843.

Research output: Contribution to journalArticle

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