The sign of Leser-Trelát and malignant acanthosis nigricans associated with fallopian tube carcinoma

Lindsey West, Matthew J Carlson, Luke Wallis, Heather W. Goff

Research output: Contribution to journalArticle

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BACKGROUND: The sign of Leser-Trelát is controversial and rarely reported in gynecologic malignancies. It is characterized by rapid development of new or enlarging seborrheic keratoses. CASE: A 78-year-old woman presented with unintentional weight loss and new-onset erythematous patches and plaques with thickened, rugated skin and stuck-on brown waxy papules on the chest and back. Her symptoms were concerning for a paraneoplastic eruption; workup revealed an elevated CA 125 level and an ovarian mass on abdominal computed tomography scan. Exploratory laparotomy revealed a stage IIIC serous fallopian tube carcinoma and a synchronous low-grade endometrioid adenocarcinoma of the endometrium. CONCLUSION: The sign of Leser-Trelát can be associated with fallopian tube carcinoma. When recognized, paraneoplastic dermatoses can prompt clinicians to initiate a workup for occult malignancy.

Original languageEnglish (US)
Pages (from-to)1116-1119
Number of pages4
JournalObstetrics and gynecology
Issue number5
Publication statusPublished - Jan 1 2018


ASJC Scopus subject areas

  • Obstetrics and Gynecology

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