The social network of PELP1 and its implications in breast and prostate cancers

Vijay K. Gonugunta, Lu Miao, Gangadhara R. Sareddy, Preethi Ravindranathan, Ratna Vadlamudi, Ganesh V. Raj

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

Proline, glutamic acid- and leucine-rich protein 1 (PELP1) is a multi-domain scaffold protein that serves as a platform for various protein-protein interactions between steroid receptors (SRs) and signaling factors and cell cycle, transcriptional, cytoskeletal, and epigenetic remodelers. PELP1 is known to be a coregulator of transcription and participates in the nuclear and extranuclear functions of SRs, ribosome biogenesis, and cell cycle progression. The expression and localization of PELP1 are dysregulated in hormonal cancers including breast and prostate cancers. This review focuses on the interactive functions and therapeutic and prognostic significance of PELP1 in breast and prostate cancers.

Original languageEnglish (US)
Pages (from-to)T79-T86
JournalEndocrine-Related Cancer
Volume21
Issue number4
DOIs
StatePublished - Aug 2014

Keywords

  • Coregulator
  • Epigenetics
  • Genomic signaling
  • Hormonal cancers
  • Interactome
  • Network
  • Nongenomic signaling
  • PELP1
  • Steroid receptors

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Oncology
  • Endocrinology
  • Cancer Research

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