The synthesis of a new probe for PET imaging reporter gene HSV1-tk: 2-Amino-6-[18F] fluoro-9- (4-hydroxy-3-hydroxymethylbutyl) purine (6-[18F]fluoropenciclovir)

Hancheng Cai; Duanzhi Yin; Lan Zhang; Yongxian Wang

doi:10.1002/jlcr.1080

The synthesis of a new probe for PET imaging reporter gene HSV1-tk: 2-Amino-6-[¹⁸F] fluoro-9- (4-hydroxy-3-hydroxymethylbutyl) purine (6-[¹⁸F]fluoropenciclovir)

Hancheng Cai, Duanzhi Yin, Lan Zhang, Yongxian Wang

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The one step radiosynthesis of 2-amino-6- [¹⁸F]fluoro-9-(4- hydroxy-3-hydroxymethyl-butyl) purine (6-[¹⁸F]fluoropenciclovir) 6 is reported. Radiolabeled product 6-[¹⁸F]fluoropenciclovir 6 was prepared by radiofluorination of compound 4 with [¹⁸F]KF and isolated by a silica Sep-Pak cartridge. The radiochemical yield of compound 6 was 45-55% decay corrected (d.c.) in six runs with radiochemical purity >98% and the radiosynthesis time was 35-42 min from end of bombardment (EOB).

Original language	English (US)
Pages (from-to)	653-661
Number of pages	9
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	49
Issue number	7
DOIs	https://doi.org/10.1002/jlcr.1080
State	Published - Jun 2006

Keywords

Fluorine-18
Penciclovir
Radiofluorination
Synthesis

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Radiology Nuclear Medicine and imaging
Drug Discovery
Spectroscopy
Organic Chemistry

Access to Document

10.1002/jlcr.1080

Cite this

The synthesis of a new probe for PET imaging reporter gene HSV1-tk: 2-Amino-6-[¹⁸F] fluoro-9- (4-hydroxy-3-hydroxymethylbutyl) purine (6-[¹⁸F]fluoropenciclovir). / Cai, Hancheng; Yin, Duanzhi; Zhang, Lan et al.
In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 49, No. 7, 06.2006, p. 653-661.

Research output: Contribution to journal › Article › peer-review

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abstract = "The one step radiosynthesis of 2-amino-6- [18F]fluoro-9-(4- hydroxy-3-hydroxymethyl-butyl) purine (6-[18F]fluoropenciclovir) 6 is reported. Radiolabeled product 6-[18F]fluoropenciclovir 6 was prepared by radiofluorination of compound 4 with [18F]KF and isolated by a silica Sep-Pak cartridge. The radiochemical yield of compound 6 was 45-55% decay corrected (d.c.) in six runs with radiochemical purity >98% and the radiosynthesis time was 35-42 min from end of bombardment (EOB).",

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