The synthesis of a new probe for PET imaging reporter gene HSV1-tk: 2-Amino-6-[18F] fluoro-9- (4-hydroxy-3-hydroxymethylbutyl) purine (6-[18F]fluoropenciclovir)

Hancheng Cai, Duanzhi Yin, Lan Zhang, Yongxian Wang

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The one step radiosynthesis of 2-amino-6- [18F]fluoro-9-(4- hydroxy-3-hydroxymethyl-butyl) purine (6-[18F]fluoropenciclovir) 6 is reported. Radiolabeled product 6-[18F]fluoropenciclovir 6 was prepared by radiofluorination of compound 4 with [18F]KF and isolated by a silica Sep-Pak cartridge. The radiochemical yield of compound 6 was 45-55% decay corrected (d.c.) in six runs with radiochemical purity >98% and the radiosynthesis time was 35-42 min from end of bombardment (EOB).

Original languageEnglish (US)
Pages (from-to)653-661
Number of pages9
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume49
Issue number7
DOIs
StatePublished - Jun 1 2006

Keywords

  • Fluorine-18
  • Penciclovir
  • Radiofluorination
  • Synthesis

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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