Abstract
We have analyzed t(1;14)(p32;q11) chromosome translocations from two patients with T cell acute lymphocytic leukemia. The chromosome 1 breakpoints of these patients lie within a kilobasepair of each other, and thus define a genetic locus (designated tal) involved in T cell oncogenesis. Moreover, we have identified sequences within tal that potentially encode an amphipathic helix-loop-helix motif, a DNA-binding domain found in a variety of proteins that control cell growth and differentiation. The homology domain of tal is especially related to that of lyl-1, a gene on chromosome 19 that has also been implicated in T cell oncogenesis. Hence, tal and lyl-1 encode a distinct family of helix-loop-helix proteins involved in the malignant development of lymphocytes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 415-424 |
| Number of pages | 10 |
| Journal | EMBO Journal |
| Volume | 9 |
| Issue number | 2 |
| State | Published - 1990 |
Fingerprint
Keywords
- Chromosome translocation
- Helix - Loop - Helix motif
- T cell acute lymphocytic leukemia
- Tal gene
ASJC Scopus subject areas
- Genetics
- Cell Biology
Cite this
The tal gene undergoes chromosome translocation in T cell leukemia potentially encodes a helix - Loop - helix protein. / Chen, Qi; Cheng, Jiin Tsuey; Tsai, Li Huei; Schneider, Nancy; Buchanan, George; Carroll, Andrew; Crist, William; Ozanne, Bradford; Siciliano, Michael J.; Baer, Richard.
In: EMBO Journal, Vol. 9, No. 2, 1990, p. 415-424.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The tal gene undergoes chromosome translocation in T cell leukemia potentially encodes a helix - Loop - helix protein
AU - Chen, Qi
AU - Cheng, Jiin Tsuey
AU - Tsai, Li Huei
AU - Schneider, Nancy
AU - Buchanan, George
AU - Carroll, Andrew
AU - Crist, William
AU - Ozanne, Bradford
AU - Siciliano, Michael J.
AU - Baer, Richard
PY - 1990
Y1 - 1990
N2 - We have analyzed t(1;14)(p32;q11) chromosome translocations from two patients with T cell acute lymphocytic leukemia. The chromosome 1 breakpoints of these patients lie within a kilobasepair of each other, and thus define a genetic locus (designated tal) involved in T cell oncogenesis. Moreover, we have identified sequences within tal that potentially encode an amphipathic helix-loop-helix motif, a DNA-binding domain found in a variety of proteins that control cell growth and differentiation. The homology domain of tal is especially related to that of lyl-1, a gene on chromosome 19 that has also been implicated in T cell oncogenesis. Hence, tal and lyl-1 encode a distinct family of helix-loop-helix proteins involved in the malignant development of lymphocytes.
AB - We have analyzed t(1;14)(p32;q11) chromosome translocations from two patients with T cell acute lymphocytic leukemia. The chromosome 1 breakpoints of these patients lie within a kilobasepair of each other, and thus define a genetic locus (designated tal) involved in T cell oncogenesis. Moreover, we have identified sequences within tal that potentially encode an amphipathic helix-loop-helix motif, a DNA-binding domain found in a variety of proteins that control cell growth and differentiation. The homology domain of tal is especially related to that of lyl-1, a gene on chromosome 19 that has also been implicated in T cell oncogenesis. Hence, tal and lyl-1 encode a distinct family of helix-loop-helix proteins involved in the malignant development of lymphocytes.
KW - Chromosome translocation
KW - Helix - Loop - Helix motif
KW - T cell acute lymphocytic leukemia
KW - Tal gene
UR - http://www.scopus.com/inward/record.url?scp=0025014636&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025014636&partnerID=8YFLogxK
M3 - Article
C2 - 2303035
AN - SCOPUS:0025014636
VL - 9
SP - 415
EP - 424
JO - EMBO Journal
JF - EMBO Journal
SN - 0261-4189
IS - 2
ER -