The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix - loop - helix protein

Qi Chen, Jiin Tsuey Cheng, Li Huei Tsai, Nancy Schneider, George Buchanan, Andrew Carroll, William Crist, Bradford Ozanne, Michael J. Siciliano, Richard Baer

Research output: Contribution to journalArticle

270 Scopus citations

Abstract

We have analyzed t(1;14)(p32;q11) chromosome translocations from two patients with T cell acute lymphocytic leukemia. The chromosome 1 breakpoints of these patients lie within a kilobasepair of each other, and thus define a genetic locus (designated tal) involved in T cell oncogenesis. Moreover, we have identified sequences within tal that potentially encode an amphipathic helix-loop-helix motif, a DNA-binding domain found in a variety of proteins that control cell growth and differentiation. The homology domain of tal is especially related to that of lyl-1, a gene on chromosome 19 that has also been implicated in T cell oncogenesis. Hence, tal and lyl-1 encode a distinct family of helix-loop-helix proteins involved in the malignant development of lymphocytes.

Original languageEnglish (US)
Pages (from-to)415-424
Number of pages10
JournalEMBO Journal
Volume9
Issue number2
DOIs
StatePublished - 1990

Keywords

  • Chromosome translocation
  • T cell acute lymphocytic leukemia
  • helix-loop-helix motif
  • tal gene

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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    Chen, Q., Cheng, J. T., Tsai, L. H., Schneider, N., Buchanan, G., Carroll, A., Crist, W., Ozanne, B., Siciliano, M. J., & Baer, R. (1990). The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix - loop - helix protein. EMBO Journal, 9(2), 415-424. https://doi.org/10.1002/j.1460-2075.1990.tb08126.x