The Toxicology Investigators Consortium Case Registry—the 2013 Experience

Sean H. Rhyee, Lynn Farrugia, Timothy Wiegand, Eric A. Smith, Paul M. Wax, Jeffrey Brent

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The Toxicology Investigators Consortium (ToxIC) Case Registry was established in 2010 by the American College of Medical Toxicology. The Registry includes all medical toxicology consultations performed at participating sites. This report summarizes the Registry data for 2013. A query of the ToxIC Registry was carried out for the dates of January 1 through December 31, 2013. Specific data reviewed for analysis included demographics (age, gender), source of consultation, reasons for consultation, agents involved in toxicological exposures, signs, symptoms and clinical findings, and treatment. A total of 8,598 cases were entered into the Registry in 2013. Females accounted for 49.2 % of cases, males for 47.7 %, and gender was not reported in 3.1 %. The majority of patients (63.4 %) were adults between the ages of 19 and 65 years. There were 93 fatalities (1.1 %). Most referrals for medical toxicology consultation originated from the emergency department (59.7 %) or inpatient services (16.7 %). Exposures to pharmaceutical products (intentional and unintentional) made up 50.0 % of cases. Illicit drug abuse (8.0 %) and adverse drug reactions (ADRs) (4.8 %) were the next most frequent reasons for consultation. Similar to past years, nonopioid analgesics, sedative-hypnotics, and opioids were the most commonly encountered agents. Symptoms or clinical findings were documented in 71.1 % of patients. Of all cases, 54.6 % required some form of medical treatment (antidotes, antivenom, chelation, specific types of supportive care). This report serves as a comprehensive survey of medical toxicology practice within participating institutions. Prior trends continued to apply this year and indicate analgesic (opioid and nonopioid), sedative-hypnotic/muscle relaxant agents, illicit drug use, and ADRs continue to be major toxicological problems. Cases requiring medical toxicology consultation in 2013 predominantly involved pharmaceuticals and illicit drugs. Reasons for these drug exposures were diverse and included intentional overdose, unintentional exposure, withdrawal syndromes, and ADRs. Nonopioid analgesics, sedative-hypnotic agents, and opioids remained the most frequently encountered agent classes. While over half of cases required some form of medical treatment, fatalities were uncommon.

Original languageEnglish (US)
Pages (from-to)342-359
Number of pages18
JournalJournal of Medical Toxicology
Volume10
Issue number4
DOIs
StatePublished - Dec 3 2014

Keywords

  • Epidemiology
  • Overdose
  • Poisoning

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

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    Rhyee, S. H., Farrugia, L., Wiegand, T., Smith, E. A., Wax, P. M., & Brent, J. (2014). The Toxicology Investigators Consortium Case Registry—the 2013 Experience. Journal of Medical Toxicology, 10(4), 342-359. https://doi.org/10.1007/s13181-014-0417-0