Repeated infusions of calcium gluconate were given to six men with idiopathic osteoporosis; bone morphology was studied by microradiography. In three patients the relative surface area of bone showing the pattern of new bone formation was initially low; in all, it returned to the normal range with the infusions. In four patients the relative area showing resorption was initially high; in all, it returned to normal with the infusions. The results are interpreted to support the suggestion that idiopathic osteoporosis results from imbalance between parathyroid hormone (PTH) secretion and thyrocalcitonin (TCT) secretion and that calcium (Ca) infusion suppresses the former and stimulates the latter.
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