The use of anti-ricin antibodies to protect mice intoxicated with ricin

B. M J Foxwell, Simone I. Detre, T. A. Donovan, P. E. Thorpe

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

Antibodies raised in rabbits to ricin or its constituent polypeptide chains are effective at securing mice from ricin intoxication if given soon enough after administration of the toxin. The maximum safe period for intravenous injection of 100 μg antibody is 40 min after intravenous injection of 1 μg ricin, increasing to 640 min in the case of subcutaneously injected ricine. The antibodies raised against the isolated A and B chains are as effective as those against whole ricin. The antibody is as effective when administered intracerebrally as by the intravenous route; this result, combined with the very high toxicity for ricin administrered intracerebrally suggests a neurotoxic role for the lectin.

Original languageEnglish (US)
Pages (from-to)79-88
Number of pages10
JournalToxicology
Volume34
Issue number1
DOIs
StatePublished - Jan 1985

Keywords

  • Anti-ricin antibodies
  • CNS toxicity
  • Ricin
  • Ricin A-chain
  • Ricin B-chain
  • Ricin antidote
  • Ricin poisoning

ASJC Scopus subject areas

  • Toxicology

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    Foxwell, B. M. J., Detre, S. I., Donovan, T. A., & Thorpe, P. E. (1985). The use of anti-ricin antibodies to protect mice intoxicated with ricin. Toxicology, 34(1), 79-88. https://doi.org/10.1016/0300-483X(85)90080-0