The use of gated cine phase contrast and MR venography in achondroplasia

N. Rollins, T. Booth, K. Shapiro

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objects: Foramen magnum and jugular foramen stenosis, well-known problems in achondroplasia, may result in brain stem compression and venous outflow obstruction, respectively. We studied a series of children with achondroplasia using gated cine phase contrast (PC) CSF flow studies to evaluate CSF dynamics across the foramen magnum and MR venography (MRV) to depict obstructed venous drainage. Methods: Ten patients (9 months to 11 years, mean 2.85 years) were referred for possible brain stem compression. MRI included routine sequences, cine PC with velocity encoding (VENC) = 5 cm/s, and MRV. Six patients, including the asymptomatic patient, had brain stem compression without tonsillar herniation; two had tonsillar herniation; and two had neither brain stem compression nor tonsillar herniation. Abnormal tonsillar movement was seen only with tonsillar herniation. MRV showed steno-occlusive disease of the internal jugular vein (IJV) in nine patients, sigmoid sinus in four, and absent or hypoplastic transverse sinus in seven. Veno-occlusive disease was not progressive. No patient had massive hydrocephalus, although larger ventricles were associated with more profuse venous collateral formation and more severe degrees of IJV stenosis. Three patients have undergone CSF diversion. Conclusions: MR imaging may be useful in defining the pathophysiology of brain stem compression and hydrocephalus in achondroplasia.

Original languageEnglish (US)
Pages (from-to)569-577
Number of pages9
JournalChild's Nervous System
Volume16
Issue number9
StatePublished - 2000

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Achondroplasia
Phlebography
Encephalocele
Brain Stem
Foramen Magnum
Jugular Veins
Hydrocephalus
Pathologic Constriction
Transverse Sinuses
Dyskinesias
Sigmoid Colon
Drainage
Neck

Keywords

  • Achondroplasia
  • Hydrocephalus
  • MR venography

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

The use of gated cine phase contrast and MR venography in achondroplasia. / Rollins, N.; Booth, T.; Shapiro, K.

In: Child's Nervous System, Vol. 16, No. 9, 2000, p. 569-577.

Research output: Contribution to journalArticle

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