The use of psychoeducation for a patient with hepatitis C and psychiatric illness in preparation for antiviral therapy: A case report and discussion

Barry A. Hong, Carol S North, David E. Pollio, Anna Abbacchi, Christine Debold, Sunday A. Adewuyi, Mauricio Lisker-Melman

Research output: Contribution to journalArticle

10 Scopus citations


The standard of care treatment for chronic hepatitis C viral infection (HCV) is a combination of pegylated interferon alfa and ribavirin for 24-48 weeks according to the virus genotype. This therapy is known to have multiple neuropsychiatric side effects. A major concern when evaluating a patient for HCV treatment with a known history of a psychiatric disorder is the risk that the patient's psychiatric disorder will flare or become unmanageable. The possibility of precipitating depression, confusion, mania, psychosis, hallucinations, or suicidal ideation or attempt is frequently an obstacle to treatment. We present the case of a 50 year-old man with HCV and an extensive psychiatric history involving alcoholism, depression, and suicidality who participated in a psychoeducation group to help prepare him for treatment with pegylated interferon alfa/ribavirin therapy. Though the patient derived much benefit from the psychoeducation group, by the time of evaluation for HCV treatment two months after the group ended he had relapsed back into a depressive episode with suicidal thoughts. His acute psychiatric status made him unacceptable for pegylated interferon alfa/ribavirin therapy. Psychoeducation groups show promise for helping patients with chronic medical illness to be ready for and endure intensive medical treatment that has substantial psychiatric side effects. The challenge is to help patients overcome barriers to treatment, particularly psychosocial problems, because available treatments are increasingly effective.

Original languageEnglish (US)
Pages (from-to)99-107
Number of pages9
JournalJournal of Clinical Psychology in Medical Settings
Issue number1
StatePublished - Mar 1 2011



  • Antiviral therapy
  • Hepatitis C
  • Psychiatric illness
  • Psychoeducation

ASJC Scopus subject areas

  • Clinical Psychology

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