@article{b13f8cb465e14bd0bd85a2af458bf48b,
title = "The where, what, and when of membrane protein degradation in neurons",
abstract = "Membrane protein turnover and degradation are required for the function and health of all cells. Neurons may live for the entire lifetime of an organism and are highly polarized cells with spatially segregated axonal and dendritic compartments. Both longevity and morphological complexity represent challenges for regulated membrane protein degradation. To investigate how neurons cope with these challenges, an increasing number of recent studies investigated local, cargo-specific protein sorting, and degradation at axon terminals and in dendritic processes. In this review, we explore the current answers to the ensuing questions of where, what, and when membrane proteins are degraded in neurons.",
keywords = "autophagy, endosome, lysosome, membrane degradation, neuronal maintenance",
author = "Jin, {Eugene Jennifer} and Kiral, {Ferdi Ridvan} and Hiesinger, {Peter Robin}",
note = "Funding Information: Contract grant sponsor: National Institute of Health (Neuro-Cure Cluster Berlin); contract grant numbers: RO1EY018884, RO1EY023333. Funding Information: Contract grant sponsor: Deutsche Forschungsgemeinschaft; contract grant numbers: SFB958 and SFB/TRR186. Funding Information: Contract grant sponsor: DFG; contract grant number: SFB958. {\textcopyright} 2017 The Authors Developmental Neurobiology Published by Wiley Periodicals, Inc. Published online 6 November 2017 in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/dneu.22534 This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Funding Information: Contract grant sponsor: NIH; contract grant numbers: T32 NS069562, F31 NS084774. Publisher Copyright: {\textcopyright} 2017 The Authors Developmental Neurobiology Published by Wiley Periodicals, Inc.",
year = "2018",
month = mar,
doi = "10.1002/dneu.22534",
language = "English (US)",
volume = "78",
pages = "283--297",
journal = "Developmental Neurobiology",
issn = "1932-8451",
publisher = "John Wiley and Sons Inc.",
number = "3",
}