The where, what, and when of membrane protein degradation in neurons

Eugene Jennifer Jin, Ferdi Ridvan Kiral, Peter Robin Hiesinger

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Membrane protein turnover and degradation are required for the function and health of all cells. Neurons may live for the entire lifetime of an organism and are highly polarized cells with spatially segregated axonal and dendritic compartments. Both longevity and morphological complexity represent challenges for regulated membrane protein degradation. To investigate how neurons cope with these challenges, an increasing number of recent studies investigated local, cargo-specific protein sorting, and degradation at axon terminals and in dendritic processes. In this review, we explore the current answers to the ensuing questions of where, what, and when membrane proteins are degraded in neurons.

Original languageEnglish (US)
JournalDevelopmental Neurobiology
DOIs
StateAccepted/In press - 2017

Fingerprint

Proteolysis
Membrane Proteins
Neurons
Presynaptic Terminals
Protein Transport
Health

Keywords

  • Autophagy
  • Endosome
  • Lysosome
  • Membrane degradation
  • Neuronal maintenance

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

The where, what, and when of membrane protein degradation in neurons. / Jin, Eugene Jennifer; Kiral, Ferdi Ridvan; Hiesinger, Peter Robin.

In: Developmental Neurobiology, 2017.

Research output: Contribution to journalArticle

Jin, Eugene Jennifer ; Kiral, Ferdi Ridvan ; Hiesinger, Peter Robin. / The where, what, and when of membrane protein degradation in neurons. In: Developmental Neurobiology. 2017.
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