Abstract
Membrane protein turnover and degradation are required for the function and health of all cells. Neurons may live for the entire lifetime of an organism and are highly polarized cells with spatially segregated axonal and dendritic compartments. Both longevity and morphological complexity represent challenges for regulated membrane protein degradation. To investigate how neurons cope with these challenges, an increasing number of recent studies investigated local, cargo-specific protein sorting, and degradation at axon terminals and in dendritic processes. In this review, we explore the current answers to the ensuing questions of where, what, and when membrane proteins are degraded in neurons.
| Original language | English (US) |
|---|---|
| Journal | Developmental Neurobiology |
| DOIs | |
| State | Accepted/In press - 2017 |
Fingerprint
Keywords
- Autophagy
- Endosome
- Lysosome
- Membrane degradation
- Neuronal maintenance
ASJC Scopus subject areas
- Developmental Neuroscience
- Cellular and Molecular Neuroscience
Cite this
The where, what, and when of membrane protein degradation in neurons. / Jin, Eugene Jennifer; Kiral, Ferdi Ridvan; Hiesinger, Peter Robin.
In: Developmental Neurobiology, 2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The where, what, and when of membrane protein degradation in neurons
AU - Jin, Eugene Jennifer
AU - Kiral, Ferdi Ridvan
AU - Hiesinger, Peter Robin
PY - 2017
Y1 - 2017
N2 - Membrane protein turnover and degradation are required for the function and health of all cells. Neurons may live for the entire lifetime of an organism and are highly polarized cells with spatially segregated axonal and dendritic compartments. Both longevity and morphological complexity represent challenges for regulated membrane protein degradation. To investigate how neurons cope with these challenges, an increasing number of recent studies investigated local, cargo-specific protein sorting, and degradation at axon terminals and in dendritic processes. In this review, we explore the current answers to the ensuing questions of where, what, and when membrane proteins are degraded in neurons.
AB - Membrane protein turnover and degradation are required for the function and health of all cells. Neurons may live for the entire lifetime of an organism and are highly polarized cells with spatially segregated axonal and dendritic compartments. Both longevity and morphological complexity represent challenges for regulated membrane protein degradation. To investigate how neurons cope with these challenges, an increasing number of recent studies investigated local, cargo-specific protein sorting, and degradation at axon terminals and in dendritic processes. In this review, we explore the current answers to the ensuing questions of where, what, and when membrane proteins are degraded in neurons.
KW - Autophagy
KW - Endosome
KW - Lysosome
KW - Membrane degradation
KW - Neuronal maintenance
UR - http://www.scopus.com/inward/record.url?scp=85030031556&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85030031556&partnerID=8YFLogxK
U2 - 10.1002/dneu.22534
DO - 10.1002/dneu.22534
M3 - Article
C2 - 28884504
AN - SCOPUS:85030031556
JO - Developmental Neurobiology
JF - Developmental Neurobiology
SN - 1932-8451
ER -