Therapeutic approaches for cardiac regeneration and repair

Hisayuki Hashimoto, Eric N. Olson, Rhonda Bassel-Duby

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Ischaemic heart disease is a leading cause of death worldwide. Injury to the heart is followed by loss of the damaged cardiomyocytes, which are replaced with fibrotic scar tissue. Depletion of cardiomyocytes results in decreased cardiac contraction, which leads to pathological cardiac dilatation, additional cardiomyocyte loss, and mechanical dysfunction, culminating in heart failure. This sequential reaction is defined as cardiac remodelling. Many therapies have focused on preventing the progressive process of cardiac remodelling to heart failure. However, after patients have developed end-stage heart failure, intervention is limited to heart transplantation. One of the main reasons for the dramatic injurious effect of cardiomyocyte loss is that the adult human heart has minimal regenerative capacity. In the past 2 decades, several strategies to repair the injured heart and improve heart function have been pursued, including cellular and noncellular therapies. In this Review, we discuss current therapeutic approaches for cardiac repair and regeneration, describing outcomes, limitations, and future prospects of preclinical and clinical trials of heart regeneration. Substantial progress has been made towards understanding the cellular and molecular mechanisms regulating heart regeneration, offering the potential to control cardiac remodelling and redirect the adult heart to a regenerative state.

Original languageEnglish (US)
Pages (from-to)1-16
Number of pages16
JournalNature Reviews Cardiology
DOIs
StateAccepted/In press - Jun 5 2018

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Regeneration
Cardiac Myocytes
Heart Failure
Therapeutics
Heart Injuries
Pathologic Dilatations
Heart Transplantation
Cicatrix
Myocardial Ischemia
Cause of Death
Clinical Trials

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Therapeutic approaches for cardiac regeneration and repair. / Hashimoto, Hisayuki; Olson, Eric N.; Bassel-Duby, Rhonda.

In: Nature Reviews Cardiology, 05.06.2018, p. 1-16.

Research output: Contribution to journalArticle

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