Therapeutic Enzyme-Responsive Nanoparticles for Targeted Delivery and Accumulation in Tumors

Cassandra E. Callmann, Christopher V. Barback, Matthew P. Thompson, David J. Hall, Robert F. Mattrey, Nathan C. Gianneschi

Research output: Contribution to journalArticle

128 Scopus citations

Abstract

An enzyme-responsive, paclitaxel-loaded nanoparticle is described and assessed in vivo in a human fibrosarcoma murine xenograft. This work represents a proof-of-concept study demonstrating the utility of enzyme-responsive nanoscale drug carriers capable of targeted accumulation and retention in tumor tissue in response to overexpressed endogenous enzymes.

Original languageEnglish (US)
Pages (from-to)4611-4615
Number of pages5
JournalAdvanced Materials
Volume27
Issue number31
DOIs
StatePublished - Aug 1 2015

Keywords

  • drug delivery
  • enzyme-responsive
  • nanomaterials
  • self-assembly
  • stimuli-responsive

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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  • Cite this

    Callmann, C. E., Barback, C. V., Thompson, M. P., Hall, D. J., Mattrey, R. F., & Gianneschi, N. C. (2015). Therapeutic Enzyme-Responsive Nanoparticles for Targeted Delivery and Accumulation in Tumors. Advanced Materials, 27(31), 4611-4615. https://doi.org/10.1002/adma.201501803