Therapeutic potential of small interfering RNA for central nervous system diseases

Amy E. Lovett-Racke, Petra D. Cravens, Anne R. Gocke, Michael K. Racke, Olaf Stüve

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

RNA interference (RNAi) is an evolutionarily conserved mechanism to degrade messenger RNA (mRNA) that has sequence homology to small double-stranded RNA (dsRNA). It is believed that the normal biological function of RNAi is to protect the host cells from RNA viruses and transposons, which can jeopardize the genome. Production of dsRNA in the host cell signals a series of events that ultimately results in the degradation of complementary mRNA. Recently, small interfering RNA (siRNA) has been used to study the function and significance of a vast number of genes in a variety of cell types. In the future, siRNA may have tremendous potential as gene-specific therapeutic agents for the treatment of many diseases. We discuss the potential role of siRNA as a novel therapeutic strategy for several central nervous system (CNS) diseases.

Original languageEnglish (US)
Pages (from-to)1810-1813
Number of pages4
JournalArchives of Neurology
Volume62
Issue number12
DOIs
StatePublished - Dec 2005

Fingerprint

Central Nervous System Diseases
Small Interfering RNA
Double-Stranded RNA
RNA Interference
Complementary RNA
Messenger RNA
RNA Viruses
Sequence Homology
Genes
Therapeutics
Genome
Central Nervous System
Cells
Gene
Interference

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Therapeutic potential of small interfering RNA for central nervous system diseases. / Lovett-Racke, Amy E.; Cravens, Petra D.; Gocke, Anne R.; Racke, Michael K.; Stüve, Olaf.

In: Archives of Neurology, Vol. 62, No. 12, 12.2005, p. 1810-1813.

Research output: Contribution to journalArticle

Lovett-Racke, Amy E. ; Cravens, Petra D. ; Gocke, Anne R. ; Racke, Michael K. ; Stüve, Olaf. / Therapeutic potential of small interfering RNA for central nervous system diseases. In: Archives of Neurology. 2005 ; Vol. 62, No. 12. pp. 1810-1813.
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