Therapy for localized Ewing's sarcoma of bone

F. A. Hayes, E. I. Thompson, W. H. Meyer, L. Kun, D. Parham, B. Rao, M. Kumar, M. Hancock, L. Parvey, L. Magill, H. O. Hustu

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Abstract

Fifty-two previously untreated patients with localized Ewing's sarcoma of bone were treated with nonintensive chemotherapy in combination with surgery or radiation therapy (RT). RT was delivered to limited volumes in a dose dependent on the initial response to induction chemotherapy (30 to 35 Gy v 50 to 55 Gy). Fifty of the 52 patients achieved complete or partial responses with induction chemotherapy, with one nonresponding patient rendered free of tumor with surgery. Fifty patients were evaluable for local control of tumor and overall response to protocol therapy. Seventeen relapses have occurred; three metastatic, four local plus metastatic, and ten local. Two factors predicted worse disease-free survival: high WBC count (P = .03) and size of primary tumor (P = .05). Of the 14 local recurrences, 12 occurred in 28 patients who presented with primary tumors > 8 cm in size while only two of 22 patients with lesions < 8 cm had local recurrence. The Kaplan-Meier estimate of disease-free survival at 3 years is 82% for those with small lesions and 64% for those with larger lesions. Site of primary was of no prognostic value (P = .27). The 5-year survival estimate for all patients is 80% (median time on study, 3.3 years).

Original languageEnglish (US)
Pages (from-to)208-213
Number of pages6
JournalJournal of Clinical Oncology
Volume7
Issue number2
DOIs
StatePublished - Jan 1 1989

Fingerprint

Ewing's Sarcoma
Bone and Bones
Induction Chemotherapy
Recurrence
Therapeutics
Disease-Free Survival
Neoplasms
Radiotherapy
Kaplan-Meier Estimate
Combination Drug Therapy
Survival

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Hayes, F. A., Thompson, E. I., Meyer, W. H., Kun, L., Parham, D., Rao, B., ... Hustu, H. O. (1989). Therapy for localized Ewing's sarcoma of bone. Journal of Clinical Oncology, 7(2), 208-213. https://doi.org/10.1200/JCO.1989.7.2.208

Therapy for localized Ewing's sarcoma of bone. / Hayes, F. A.; Thompson, E. I.; Meyer, W. H.; Kun, L.; Parham, D.; Rao, B.; Kumar, M.; Hancock, M.; Parvey, L.; Magill, L.; Hustu, H. O.

In: Journal of Clinical Oncology, Vol. 7, No. 2, 01.01.1989, p. 208-213.

Research output: Contribution to journalArticle

Hayes, FA, Thompson, EI, Meyer, WH, Kun, L, Parham, D, Rao, B, Kumar, M, Hancock, M, Parvey, L, Magill, L & Hustu, HO 1989, 'Therapy for localized Ewing's sarcoma of bone', Journal of Clinical Oncology, vol. 7, no. 2, pp. 208-213. https://doi.org/10.1200/JCO.1989.7.2.208
Hayes FA, Thompson EI, Meyer WH, Kun L, Parham D, Rao B et al. Therapy for localized Ewing's sarcoma of bone. Journal of Clinical Oncology. 1989 Jan 1;7(2):208-213. https://doi.org/10.1200/JCO.1989.7.2.208
Hayes, F. A. ; Thompson, E. I. ; Meyer, W. H. ; Kun, L. ; Parham, D. ; Rao, B. ; Kumar, M. ; Hancock, M. ; Parvey, L. ; Magill, L. ; Hustu, H. O. / Therapy for localized Ewing's sarcoma of bone. In: Journal of Clinical Oncology. 1989 ; Vol. 7, No. 2. pp. 208-213.
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