Therapy response and outcome explained by leukemia cell of origin

Research output: Contribution to journalArticlepeer-review

Abstract

In this issue of Cancer Discovery, Cai and colleagues delineate a new mechanism that links cell of origin, the transcription factor EVI1, apoptotic priming, and therapeutic susceptibility in mixed lineage leukemia– rearranged acute myeloid leukemia. These findings establish a cell of origin–dependent program that may be leveraged by therapeutic combinations to overcome drug resistance in chemoresistant leukemias.

Original languageEnglish (US)
Pages (from-to)1445-1447
Number of pages3
JournalCancer discovery
Volume10
Issue number10
DOIs
StatePublished - Oct 2020

ASJC Scopus subject areas

  • Oncology

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