Thinking outside the Osp(G) - Kinase activation by E2-ubiquitin

Maarten F. De Jong, Neal M. Alto

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

OspG is a secreted effector kinase from the human pathogen Shigella that is required for the reduction of immune responses during Shigella infection. A new study in The EMBO Journal provides a co-crystal structure of OspG bound to UbcH5c∼Ub, revealing how a bacterial kinase can be activated by the host ubiquitin conjugation machinery. These results provide molecular insight into an enigmatic microbial virulence factor that thwarts the host immune surveillance system to cause disease.

Original languageEnglish (US)
Pages (from-to)403-404
Number of pages2
JournalEMBO Journal
Volume33
Issue number5
DOIs
StatePublished - Mar 3 2014

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ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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