Thioredoxin-1 actively maintains the pseudokinase MLKL in a reduced state to suppress disulfide bond-dependent MLKL polymer formation and necroptosis

Medicine & Life Sciences

• Necroptosis 100%
• Thioredoxins 89%
• Disulfides 74%
• Polymers 62%
• Receptor-Interacting Protein Serine-Threonine Kinases 28%
• Protein Kinases 28%
• IV 2 compound 21%
• Polymerization 20%
• N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide 20%
• Cysteine 19%
• Immunogenic Cell Death 15%
• Neoplasms 13%
• Sulfhydryl Compounds 10%
• Oxidoreductases 9%
• Small Interfering RNA 8%
• Protein Isoforms 8%
• Cell Death 7%
• Direction compound 7%
• Phosphorylation 6%
• Pharmacology 6%
• Cell Line 5%
• Inflammation 5%
• Infections 4%
• In Vitro Techniques 4%
• Therapeutics 1%

Chemical Compounds

• Disulfide 58%
• Necrosulfonamide 56%
• Cell Death 50%
• Cysteine 40%
• Thioredoxin 29%
• Protein 29%
• Polymerization Reaction 28%
• Thiol 19%
• Block Like Crystal 15%