TY - GEN
T1 - Three-dimensional evaluation of microvascular networks using contrast-enhanced ultrasound and microbubble tracking
AU - Johnson, Kenneth
AU - Oezdemir, Ipek
AU - Hoyt, Kenneth
N1 - Funding Information:
This research was supported in part by NIH grant R01EB025841. The authors acknowledge the Texas Advanced Computing Center at the University of Texas at Austin for providing HPC resources that have contributed to the research results reported in this paper. URL: http://www.tacc.utexas.edu
Publisher Copyright:
© 2020 IEEE.
PY - 2020/9/7
Y1 - 2020/9/7
N2 - Evaluating tumor microvascular networks with use of contrast-enhanced ultrasound (CEUS) imaging and one-dimensional (1D) linear array transducers have inherit limitations as tumors exist in volume space. The use of a mechanical sweep allows users to overcome this limitation. To that end, we have developed a new method by which a 1D linear array transducer can be mechanically scanned over a region-of-interest to capture a volume of data allowing for the evaluation of microvasculature structures in 3D space. After intravascular injection of a microbubble (MB) contrast agent into a developing chicken embryo, a sequence of CEUS images were acquired using a Vevo 3100 scanner (VisualSonics Inc) and taken at multiple tissue cross-sections. The CEUS images were processed with a singular value filter (SVF) to help remove any clutter signal. MB localization was performed, and frame-to-frame MB movement was analyzed to produce spatial maps depicting blood flow and velocity at each tissue cross-section. Reconstruction of all images allowed visualization of microvascular networks and blood velocity distribution in volume space.
AB - Evaluating tumor microvascular networks with use of contrast-enhanced ultrasound (CEUS) imaging and one-dimensional (1D) linear array transducers have inherit limitations as tumors exist in volume space. The use of a mechanical sweep allows users to overcome this limitation. To that end, we have developed a new method by which a 1D linear array transducer can be mechanically scanned over a region-of-interest to capture a volume of data allowing for the evaluation of microvasculature structures in 3D space. After intravascular injection of a microbubble (MB) contrast agent into a developing chicken embryo, a sequence of CEUS images were acquired using a Vevo 3100 scanner (VisualSonics Inc) and taken at multiple tissue cross-sections. The CEUS images were processed with a singular value filter (SVF) to help remove any clutter signal. MB localization was performed, and frame-to-frame MB movement was analyzed to produce spatial maps depicting blood flow and velocity at each tissue cross-section. Reconstruction of all images allowed visualization of microvascular networks and blood velocity distribution in volume space.
KW - Contrast agent
KW - Contrast-enhanced ultrasound
KW - Microbubbles
KW - Microvascular networks
KW - Ultrasound
KW - Volume imaging
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U2 - 10.1109/IUS46767.2020.9251525
DO - 10.1109/IUS46767.2020.9251525
M3 - Conference contribution
AN - SCOPUS:85097869264
T3 - IEEE International Ultrasonics Symposium, IUS
BT - IUS 2020 - International Ultrasonics Symposium, Proceedings
PB - IEEE Computer Society
T2 - 2020 IEEE International Ultrasonics Symposium, IUS 2020
Y2 - 7 September 2020 through 11 September 2020
ER -