Three-dimensional printed modeling of diffuse low-grade gliomas and associated white matter tract anatomy

Jayesh P. Thawani, Nickpreet Singh, Jared M. Pisapia, Kalil G. Abdullah, Drew Parker, Bryan A. Pukenas, Eric L. Zager, Ragini Verma, Steven Brem

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

BACKGROUND: Diffuse low-grade gliomas (DLGGs) represent several pathological entities that infiltrate and invade cortical and subcortical structures in the brain. OBJECTIVE: To describe methods for rapid prototyping of DLGGs and surgically relevant anatomy. METHODS: Using high-definition imaging data and rapid prototyping technologies, we were able to generate 3 patient DLGGs to scale and represent the associated white matter tracts in 3 dimensions using advanced diffusion tensor imaging techniques. RESULTS: This report represents a novel application of 3-dimensional (3-D) printing in neurosurgery and a means to model individualized tumors in 3-D space with respect to subcortical white matter tract anatomy. Faculty and resident evaluations of this technology were favorable at our institution. CONCLUSION: Developing an understanding of the anatomic relationships existing within individuals is fundamental to successful neurosurgical therapy. Imaging-based rapid prototyping may improve on our ability to plan for and treat complex neuro-oncologic pathology.

Original languageEnglish (US)
Pages (from-to)635-645
Number of pages11
JournalClinical Neurosurgery
Volume80
Issue number4
DOIs
StatePublished - Apr 1 2017
Externally publishedYes

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Keywords

  • 3-D printing
  • Brain tumor modeling
  • Diffusion tensor imaging

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Thawani, J. P., Singh, N., Pisapia, J. M., Abdullah, K. G., Parker, D., Pukenas, B. A., Zager, E. L., Verma, R., & Brem, S. (2017). Three-dimensional printed modeling of diffuse low-grade gliomas and associated white matter tract anatomy. Clinical Neurosurgery, 80(4), 635-645. https://doi.org/10.1093/neuros/nyx009