Three-dimensional thermal therapy using multiple planar ultrasound transducers with real-time MR temperature feedback in gel phantoms

Kee Tang, Matthew Asselin, Mathieu Burtnyk, Rajiv Chopra, Michael Bronskill

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

High intensity ultrasound delivered transurethrally is a promising approach for the treatment of localized prostate cancer. The use of multiple planar ultrasound transducers mounted on an MR-compatible applicator with rotational capability can provide precise control over the spatial deposition of energy within the gland. Using MR thermometry for adaptive temperature feedback, accurately shaped three-dimensional heating patterns can potentially be achieved. The goal of this study was to evaluate the feasibility of simultaneously controlling multiple elements with real-time MR temperature feedback in gel phantoms in a 1.5T MR imager. Numerical simulations were used initially to determine treatment delivery strategies and appropriate tuning of the temperature feedback control algorithm. Two typical prostate shapes were then treated in tissue-mimicking polyacrylamide gel phantoms using a prototype system to demonstrate conformity of the thermal damage patterns to the target boundaries. Five planar gradient-echo MRI slices with a spatial resolution of 1.7x3.4x5mm and a temporal resolution of 5s were obtained. Each slice was centered on a transducer element which had a length of 9mm operating at 7.7MHz. Results showed high correlation between the desired target boundary and the 55°C isotherm with an average error of 1.0 ± 1.5mm (n=5) for shape # 1 and 1.0 ± 1.2mm (n=5) for shape # 2 across five slices with target volumes of approximately 53cm 3 and 58cm 3 respectively. The feasibility of MRI-guided active feedback for accurate, 3D, multi-planar treatments has been demonstrated and further investigation in vivo will be done.

Original languageEnglish (US)
Title of host publication8th International Symposium on Therapeutic Ultrasound
Pages309-313
Number of pages5
DOIs
StatePublished - Jul 21 2009
Event8th International Symposium on Therapeutic Ultrasound - Minneapolis, MN, United States
Duration: Sep 10 2008Sep 13 2008

Publication series

NameAIP Conference Proceedings
Volume1113
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

Other8th International Symposium on Therapeutic Ultrasound
CountryUnited States
CityMinneapolis, MN
Period9/10/089/13/08

Keywords

  • Active feedback
  • MRI-guided
  • Prostate
  • Thermal therapy
  • Transurethral

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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  • Cite this

    Tang, K., Asselin, M., Burtnyk, M., Chopra, R., & Bronskill, M. (2009). Three-dimensional thermal therapy using multiple planar ultrasound transducers with real-time MR temperature feedback in gel phantoms. In 8th International Symposium on Therapeutic Ultrasound (pp. 309-313). (AIP Conference Proceedings; Vol. 1113). https://doi.org/10.1063/1.3131436