Thromboembolic disease in COVID-19 patients: A brief narrative review

Samhati Mondal, Ashley L. Quintili, Kunal Karamchandani, Somnath Bose

Research output: Contribution to journalReview articlepeer-review

Abstract

Corona virus 2 (SARS-CoV2/ Severe Acute Respiratory Syndrome Corona Virus 2) infection has emerged as a global health crisis. Incidence of thromboembolic disease is reported to be high in SARS-CoV2 disease and is seen in a multitude of organ systems ranging from cutaneous thrombosis to pulmonary embolism, stroke or coronary thrombosis sometimes with catastrophic outcomes. Evidence points towards a key role of thromboembolism, hypercoagulability and over production of proinflammatory cytokines mimicking a "cytokine storm"which leads to multiorgan failure. This brief narrative review highlights the pathophysiology and risk factors of thromboembolic disease and provides a framework for management of anticoagulation based on the current evidence.

Original languageEnglish (US)
Article number70
JournalJournal of Intensive Care
Volume8
Issue number1
DOIs
StatePublished - Sep 14 2020
Externally publishedYes

Keywords

  • COVID-19
  • SARS-CoV2
  • coagulation
  • management
  • thromboembolism
  • thrombosis

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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