TY - GEN
T1 - Thymosin β4 and cardiac repair
AU - Shrivastava, Santwana
AU - Srivastava, Deepak
AU - Olson, Eric N.
AU - Dimaio, J. Michael
AU - Bock-Marquette, Ildiko
PY - 2010/4
Y1 - 2010/4
N2 - Hypoxic heart disease is a predominant cause of disability and death worldwide. As adult mammals are incapable of cardiac repair after infarction, the discovery of effective methods to achieve myocardial and vascular regeneration is crucial. Efforts to use stem cells to repopulate damaged tissue are currently limited by technical considerations and restricted cell potential. We discovered that the small, secreted peptide thymosin β4 (Tβ4) could be sufficiently used to inhibit myocardial cell death, stimulate vessel growth, and activate endogenous cardiac progenitors by reminding the adult heart on its embryonic program in vivo. The initiation of epicardial thickening accompanied by increase of myocardial and epicardial progenitors with or without infarction indicate that the reactivation process is independent of injury. Our results demonstrate Tβ4 to be the first known molecule able to initiate simultaneous myocardial and vascular regeneration after systemic administration in vivo. Given our findings, the utility of Tβ4 to heal cardiac injury may hold promise and warrant further investigation.
AB - Hypoxic heart disease is a predominant cause of disability and death worldwide. As adult mammals are incapable of cardiac repair after infarction, the discovery of effective methods to achieve myocardial and vascular regeneration is crucial. Efforts to use stem cells to repopulate damaged tissue are currently limited by technical considerations and restricted cell potential. We discovered that the small, secreted peptide thymosin β4 (Tβ4) could be sufficiently used to inhibit myocardial cell death, stimulate vessel growth, and activate endogenous cardiac progenitors by reminding the adult heart on its embryonic program in vivo. The initiation of epicardial thickening accompanied by increase of myocardial and epicardial progenitors with or without infarction indicate that the reactivation process is independent of injury. Our results demonstrate Tβ4 to be the first known molecule able to initiate simultaneous myocardial and vascular regeneration after systemic administration in vivo. Given our findings, the utility of Tβ4 to heal cardiac injury may hold promise and warrant further investigation.
KW - Cardiac regeneration
KW - Coronary development
KW - PKC
KW - Progenitor cells
KW - Thymosin β4
UR - http://www.scopus.com/inward/record.url?scp=77951804946&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77951804946&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2010.05468.x
DO - 10.1111/j.1749-6632.2010.05468.x
M3 - Conference contribution
C2 - 20536454
AN - SCOPUS:77951804946
SN - 9781573318013
T3 - Annals of the New York Academy of Sciences
SP - 87
EP - 96
BT - Thymosins in Health and Disease
PB - Blackwell Publishing Inc.
ER -