Time course of depression and outcome of myocardial infarction

Susmita Parashar, John S. Rumsfeld, John A. Spertus, Kimberly J. Reid, Nanette K. Wenger, Harlan M. Krumholz, Alpesh Amin, William S. Weintraub, Judith Lichtman, Nazeera Dawood, Viola Vaccarino

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

Background: Depression predicts worse outcomes after myocardial infarction (MI), but whether its time course in the month following MI has prognostic importance is unknown. Our objective was to evaluate the prognostic importance of transient, new, or persistent depression on outcomes at 6 months after MI. Methods: In a prospective registry of acute MI (Prospective Registry Evaluating outcomes after Myocardial Infarction: Events and Recovery [PREMIER]), depressive symptoms were measured in 1873 patients with the Patient Health Questionnaire (PHQ) during hospitalization and 1 month after discharge and were classified as transient (only at baseline), new (only at 1 month), or persistent (at both times). Outcomes at 6 months included (1) all-cause rehospitalization or mortality and (2) health status (angina, physical limitation, and quality of life using the Seattle Angina Questionnaire). Results: Compared with nondepressed patients, all categories of depression were associated with higher rehospitalization or mortality rates, more frequent angina, more physical limitations, and worse quality of life. The adjusted hazard ratios for rehospitalization or mortality were 1.34, 1.71, and 1.42 for transient, new, and persistent depression, respectively (all P<.05). Corresponding odds ratios were 1.62, 2.73, and 2.64 (all P<.01) for angina and 1.69, 2.25, and 3.27 (all P<.05) for physical limitation. Depressive symptoms showed a stronger association with health status compared with traditional measures of disease severity. Conclusion: Depressive symptoms after MI, irrespective of whether they persist, subside, or newly develop in the first month after hospitalization, are associated with worse outcomes after MI.

Original languageEnglish (US)
Pages (from-to)2035-2043
Number of pages9
JournalArchives of Internal Medicine
Volume166
Issue number18
DOIs
StatePublished - Oct 9 2006

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Myocardial Infarction
Depression
Health Status
Registries
Mortality
Hospitalization
Quality of Life
Odds Ratio
Health
Surveys and Questionnaires

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Parashar, S., Rumsfeld, J. S., Spertus, J. A., Reid, K. J., Wenger, N. K., Krumholz, H. M., ... Vaccarino, V. (2006). Time course of depression and outcome of myocardial infarction. Archives of Internal Medicine, 166(18), 2035-2043. https://doi.org/10.1001/archinte.166.18.2035

Time course of depression and outcome of myocardial infarction. / Parashar, Susmita; Rumsfeld, John S.; Spertus, John A.; Reid, Kimberly J.; Wenger, Nanette K.; Krumholz, Harlan M.; Amin, Alpesh; Weintraub, William S.; Lichtman, Judith; Dawood, Nazeera; Vaccarino, Viola.

In: Archives of Internal Medicine, Vol. 166, No. 18, 09.10.2006, p. 2035-2043.

Research output: Contribution to journalArticle

Parashar, S, Rumsfeld, JS, Spertus, JA, Reid, KJ, Wenger, NK, Krumholz, HM, Amin, A, Weintraub, WS, Lichtman, J, Dawood, N & Vaccarino, V 2006, 'Time course of depression and outcome of myocardial infarction', Archives of Internal Medicine, vol. 166, no. 18, pp. 2035-2043. https://doi.org/10.1001/archinte.166.18.2035
Parashar S, Rumsfeld JS, Spertus JA, Reid KJ, Wenger NK, Krumholz HM et al. Time course of depression and outcome of myocardial infarction. Archives of Internal Medicine. 2006 Oct 9;166(18):2035-2043. https://doi.org/10.1001/archinte.166.18.2035
Parashar, Susmita ; Rumsfeld, John S. ; Spertus, John A. ; Reid, Kimberly J. ; Wenger, Nanette K. ; Krumholz, Harlan M. ; Amin, Alpesh ; Weintraub, William S. ; Lichtman, Judith ; Dawood, Nazeera ; Vaccarino, Viola. / Time course of depression and outcome of myocardial infarction. In: Archives of Internal Medicine. 2006 ; Vol. 166, No. 18. pp. 2035-2043.
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abstract = "Background: Depression predicts worse outcomes after myocardial infarction (MI), but whether its time course in the month following MI has prognostic importance is unknown. Our objective was to evaluate the prognostic importance of transient, new, or persistent depression on outcomes at 6 months after MI. Methods: In a prospective registry of acute MI (Prospective Registry Evaluating outcomes after Myocardial Infarction: Events and Recovery [PREMIER]), depressive symptoms were measured in 1873 patients with the Patient Health Questionnaire (PHQ) during hospitalization and 1 month after discharge and were classified as transient (only at baseline), new (only at 1 month), or persistent (at both times). Outcomes at 6 months included (1) all-cause rehospitalization or mortality and (2) health status (angina, physical limitation, and quality of life using the Seattle Angina Questionnaire). Results: Compared with nondepressed patients, all categories of depression were associated with higher rehospitalization or mortality rates, more frequent angina, more physical limitations, and worse quality of life. The adjusted hazard ratios for rehospitalization or mortality were 1.34, 1.71, and 1.42 for transient, new, and persistent depression, respectively (all P<.05). Corresponding odds ratios were 1.62, 2.73, and 2.64 (all P<.01) for angina and 1.69, 2.25, and 3.27 (all P<.05) for physical limitation. Depressive symptoms showed a stronger association with health status compared with traditional measures of disease severity. Conclusion: Depressive symptoms after MI, irrespective of whether they persist, subside, or newly develop in the first month after hospitalization, are associated with worse outcomes after MI.",
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AU - Parashar, Susmita

AU - Rumsfeld, John S.

AU - Spertus, John A.

AU - Reid, Kimberly J.

AU - Wenger, Nanette K.

AU - Krumholz, Harlan M.

AU - Amin, Alpesh

AU - Weintraub, William S.

AU - Lichtman, Judith

AU - Dawood, Nazeera

AU - Vaccarino, Viola

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N2 - Background: Depression predicts worse outcomes after myocardial infarction (MI), but whether its time course in the month following MI has prognostic importance is unknown. Our objective was to evaluate the prognostic importance of transient, new, or persistent depression on outcomes at 6 months after MI. Methods: In a prospective registry of acute MI (Prospective Registry Evaluating outcomes after Myocardial Infarction: Events and Recovery [PREMIER]), depressive symptoms were measured in 1873 patients with the Patient Health Questionnaire (PHQ) during hospitalization and 1 month after discharge and were classified as transient (only at baseline), new (only at 1 month), or persistent (at both times). Outcomes at 6 months included (1) all-cause rehospitalization or mortality and (2) health status (angina, physical limitation, and quality of life using the Seattle Angina Questionnaire). Results: Compared with nondepressed patients, all categories of depression were associated with higher rehospitalization or mortality rates, more frequent angina, more physical limitations, and worse quality of life. The adjusted hazard ratios for rehospitalization or mortality were 1.34, 1.71, and 1.42 for transient, new, and persistent depression, respectively (all P<.05). Corresponding odds ratios were 1.62, 2.73, and 2.64 (all P<.01) for angina and 1.69, 2.25, and 3.27 (all P<.05) for physical limitation. Depressive symptoms showed a stronger association with health status compared with traditional measures of disease severity. Conclusion: Depressive symptoms after MI, irrespective of whether they persist, subside, or newly develop in the first month after hospitalization, are associated with worse outcomes after MI.

AB - Background: Depression predicts worse outcomes after myocardial infarction (MI), but whether its time course in the month following MI has prognostic importance is unknown. Our objective was to evaluate the prognostic importance of transient, new, or persistent depression on outcomes at 6 months after MI. Methods: In a prospective registry of acute MI (Prospective Registry Evaluating outcomes after Myocardial Infarction: Events and Recovery [PREMIER]), depressive symptoms were measured in 1873 patients with the Patient Health Questionnaire (PHQ) during hospitalization and 1 month after discharge and were classified as transient (only at baseline), new (only at 1 month), or persistent (at both times). Outcomes at 6 months included (1) all-cause rehospitalization or mortality and (2) health status (angina, physical limitation, and quality of life using the Seattle Angina Questionnaire). Results: Compared with nondepressed patients, all categories of depression were associated with higher rehospitalization or mortality rates, more frequent angina, more physical limitations, and worse quality of life. The adjusted hazard ratios for rehospitalization or mortality were 1.34, 1.71, and 1.42 for transient, new, and persistent depression, respectively (all P<.05). Corresponding odds ratios were 1.62, 2.73, and 2.64 (all P<.01) for angina and 1.69, 2.25, and 3.27 (all P<.05) for physical limitation. Depressive symptoms showed a stronger association with health status compared with traditional measures of disease severity. Conclusion: Depressive symptoms after MI, irrespective of whether they persist, subside, or newly develop in the first month after hospitalization, are associated with worse outcomes after MI.

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