Time-Restricted Feeding Shifts the Skin Circadian Clock and Alters UVB-Induced DNA Damage

Hong Wang, Elyse van Spyk, Qiang Liu, Mikhail Geyfman, Michael L. Salmans, Vivek Kumar, Alexander Ihler, Ning Li, Joseph S. Takahashi, Bogi Andersen

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The epidermis is a highly regenerative barrier protecting organisms from environmental insults, including UV radiation, the main cause of skin cancer and skin aging. Here, we show that time-restricted feeding (RF) shifts the phase and alters the amplitude of the skin circadian clock and affects the expression of approximately 10% of the skin transcriptome. Furthermore, a large number of skin-expressed genes are acutely regulated by food intake. Although the circadian clock is required for daily rhythms in DNA synthesis in epidermal progenitor cells, RF-induced shifts in clock phase do not alter the phase of DNA synthesis. However, RF alters both diurnal sensitivity to UVB-induced DNA damage and expression of the key DNA repair gene, Xpa. Together, our findings indicate regulation of skin function by time of feeding and emphasize a link between circadian rhythm, food intake, and skin health.

Original languageEnglish (US)
Pages (from-to)1061-1072
Number of pages12
JournalCell Reports
Volume20
Issue number5
DOIs
StatePublished - Aug 1 2017

Fingerprint

Circadian Clocks
DNA Damage
Clocks
Skin
DNA
Skin Neoplasms
Eating
Skin Aging
Genes
Circadian Rhythm
Transcriptome
Epidermis
DNA Repair
Stem Cells
Radiation
Ultraviolet radiation
Repair
Health
Aging of materials

Keywords

  • aging
  • cell cycle
  • circadian clock
  • DNA damage
  • metabolism
  • skin
  • time-restricted feeding

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Wang, H., van Spyk, E., Liu, Q., Geyfman, M., Salmans, M. L., Kumar, V., ... Andersen, B. (2017). Time-Restricted Feeding Shifts the Skin Circadian Clock and Alters UVB-Induced DNA Damage. Cell Reports, 20(5), 1061-1072. https://doi.org/10.1016/j.celrep.2017.07.022

Time-Restricted Feeding Shifts the Skin Circadian Clock and Alters UVB-Induced DNA Damage. / Wang, Hong; van Spyk, Elyse; Liu, Qiang; Geyfman, Mikhail; Salmans, Michael L.; Kumar, Vivek; Ihler, Alexander; Li, Ning; Takahashi, Joseph S.; Andersen, Bogi.

In: Cell Reports, Vol. 20, No. 5, 01.08.2017, p. 1061-1072.

Research output: Contribution to journalArticle

Wang, H, van Spyk, E, Liu, Q, Geyfman, M, Salmans, ML, Kumar, V, Ihler, A, Li, N, Takahashi, JS & Andersen, B 2017, 'Time-Restricted Feeding Shifts the Skin Circadian Clock and Alters UVB-Induced DNA Damage', Cell Reports, vol. 20, no. 5, pp. 1061-1072. https://doi.org/10.1016/j.celrep.2017.07.022
Wang H, van Spyk E, Liu Q, Geyfman M, Salmans ML, Kumar V et al. Time-Restricted Feeding Shifts the Skin Circadian Clock and Alters UVB-Induced DNA Damage. Cell Reports. 2017 Aug 1;20(5):1061-1072. https://doi.org/10.1016/j.celrep.2017.07.022
Wang, Hong ; van Spyk, Elyse ; Liu, Qiang ; Geyfman, Mikhail ; Salmans, Michael L. ; Kumar, Vivek ; Ihler, Alexander ; Li, Ning ; Takahashi, Joseph S. ; Andersen, Bogi. / Time-Restricted Feeding Shifts the Skin Circadian Clock and Alters UVB-Induced DNA Damage. In: Cell Reports. 2017 ; Vol. 20, No. 5. pp. 1061-1072.
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