Time-Restricted Feeding Shifts the Skin Circadian Clock and Alters UVB-Induced DNA Damage

Hong Wang, Elyse van Spyk, Qiang Liu, Mikhail Geyfman, Michael L. Salmans, Vivek Kumar, Alexander Ihler, Ning Li, Joseph S. Takahashi, Bogi Andersen

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

The epidermis is a highly regenerative barrier protecting organisms from environmental insults, including UV radiation, the main cause of skin cancer and skin aging. Here, we show that time-restricted feeding (RF) shifts the phase and alters the amplitude of the skin circadian clock and affects the expression of approximately 10% of the skin transcriptome. Furthermore, a large number of skin-expressed genes are acutely regulated by food intake. Although the circadian clock is required for daily rhythms in DNA synthesis in epidermal progenitor cells, RF-induced shifts in clock phase do not alter the phase of DNA synthesis. However, RF alters both diurnal sensitivity to UVB-induced DNA damage and expression of the key DNA repair gene, Xpa. Together, our findings indicate regulation of skin function by time of feeding and emphasize a link between circadian rhythm, food intake, and skin health.

Original languageEnglish (US)
Pages (from-to)1061-1072
Number of pages12
JournalCell Reports
Volume20
Issue number5
DOIs
Publication statusPublished - Aug 1 2017

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Keywords

  • aging
  • cell cycle
  • circadian clock
  • DNA damage
  • metabolism
  • skin
  • time-restricted feeding

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Wang, H., van Spyk, E., Liu, Q., Geyfman, M., Salmans, M. L., Kumar, V., ... Andersen, B. (2017). Time-Restricted Feeding Shifts the Skin Circadian Clock and Alters UVB-Induced DNA Damage. Cell Reports, 20(5), 1061-1072. https://doi.org/10.1016/j.celrep.2017.07.022