Tlr4: Central component of the sole mammalian LPS sensor

Research output: Contribution to journalArticle

592 Citations (Scopus)

Abstract

Mutations of the mouse Lps locus abolish responses to lipopolysaccharide (LPS). Positional cloning work has revealed that Lps encodes the Toll-like receptor 4 (Tlr4), which functions as the transmembrane component of the LPS receptor complex, an unduplicated pathway for the detection of endotoxin. The structurally related protein Tlr2 makes no contribution to LPS signal transduction.

Original languageEnglish (US)
Pages (from-to)20-26
Number of pages7
JournalCurrent Opinion in Immunology
Volume12
Issue number1
DOIs
StatePublished - Feb 1 2000

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Toll-Like Receptor 4
Lipopolysaccharides
CD14 Antigens
Endotoxins
Organism Cloning
Signal Transduction
Mutation
Proteins

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Tlr4 : Central component of the sole mammalian LPS sensor. / Beutler, Bruce.

In: Current Opinion in Immunology, Vol. 12, No. 1, 01.02.2000, p. 20-26.

Research output: Contribution to journalArticle

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