Tlr4: Central component of the sole mammalian LPS sensor

Bruce Beutler

doi:10.1016/S0952-7915(99)00046-1

Tlr4: Central component of the sole mammalian LPS sensor

Bruce Beutler

Research output: Contribution to journal › Review article › peer-review

661 Scopus citations

Abstract

Mutations of the mouse Lps locus abolish responses to lipopolysaccharide (LPS). Positional cloning work has revealed that Lps encodes the Toll-like receptor 4 (Tlr4), which functions as the transmembrane component of the LPS receptor complex, an unduplicated pathway for the detection of endotoxin. The structurally related protein Tlr2 makes no contribution to LPS signal transduction.

Original language	English (US)
Pages (from-to)	20-26
Number of pages	7
Journal	Current Opinion in Immunology
Volume	12
Issue number	1
DOIs	https://doi.org/10.1016/S0952-7915(99)00046-1
State	Published - Feb 1 2000

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/S0952-7915(99)00046-1

Cite this

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title = "Tlr4: Central component of the sole mammalian LPS sensor",

abstract = "Mutations of the mouse Lps locus abolish responses to lipopolysaccharide (LPS). Positional cloning work has revealed that Lps encodes the Toll-like receptor 4 (Tlr4), which functions as the transmembrane component of the LPS receptor complex, an unduplicated pathway for the detection of endotoxin. The structurally related protein Tlr2 makes no contribution to LPS signal transduction.",

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AB - Mutations of the mouse Lps locus abolish responses to lipopolysaccharide (LPS). Positional cloning work has revealed that Lps encodes the Toll-like receptor 4 (Tlr4), which functions as the transmembrane component of the LPS receptor complex, an unduplicated pathway for the detection of endotoxin. The structurally related protein Tlr2 makes no contribution to LPS signal transduction.

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Tlr4: Central component of the sole mammalian LPS sensor

Abstract

ASJC Scopus subject areas

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