TY - JOUR
T1 - TmDOTA-
T2 - A sensitive probe for MR thermometry in vivo
AU - Zuo, Chun S.
AU - Mahmood, Ashfaq
AU - Sherry, A. Dean
N1 - Funding Information:
This work was supported in part by the Whitaker Foundation (G-96-0047) and the Robert A. Welch Foundation (AT-584). C.Z. thanks helpful discussions from Drs. K. Metz, K. Hynynen, R. V. Mulkern, and Ms. D. Wolfe for editorial assistance.
PY - 2001
Y1 - 2001
N2 - The lanthanide complex, thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (TmDOTA-), has been investigated as an agent for MR thermometry in vivo. The chemical shifts of the TmDOTA- protons were highly sensitive to temperature at a clinically relevant field strength, yet insensitive to pH and the presence of Ca2+. Given the excellent stability of lanthanide-DOTA complexes and high thermal sensitivity, TmDOTA- is expected to be a good candidate for MR thermometry in vivo.
AB - The lanthanide complex, thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (TmDOTA-), has been investigated as an agent for MR thermometry in vivo. The chemical shifts of the TmDOTA- protons were highly sensitive to temperature at a clinically relevant field strength, yet insensitive to pH and the presence of Ca2+. Given the excellent stability of lanthanide-DOTA complexes and high thermal sensitivity, TmDOTA- is expected to be a good candidate for MR thermometry in vivo.
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U2 - 10.1006/jmre.2001.2356
DO - 10.1006/jmre.2001.2356
M3 - Article
C2 - 11444943
AN - SCOPUS:0035744184
SN - 1090-7807
VL - 151
SP - 101
EP - 106
JO - Journal of Magnetic Resonance
JF - Journal of Magnetic Resonance
IS - 1
ER -