TmDOTA-: A sensitive probe for MR thermometry in vivo

Chun S. Zuo, Ashfaq Mahmood, A. Dean Sherry

Research output: Contribution to journalArticle

33 Scopus citations


The lanthanide complex, thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (TmDOTA-), has been investigated as an agent for MR thermometry in vivo. The chemical shifts of the TmDOTA- protons were highly sensitive to temperature at a clinically relevant field strength, yet insensitive to pH and the presence of Ca2+. Given the excellent stability of lanthanide-DOTA complexes and high thermal sensitivity, TmDOTA- is expected to be a good candidate for MR thermometry in vivo.

Original languageEnglish (US)
Pages (from-to)101-106
Number of pages6
JournalJournal of Magnetic Resonance
Issue number1
Publication statusPublished - 2001


ASJC Scopus subject areas

  • Molecular Biology
  • Physical and Theoretical Chemistry
  • Spectroscopy
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

Cite this