TmDOTA-: A sensitive probe for MR thermometry in vivo

Chun S. Zuo, Ashfaq Mahmood, A. Dean Sherry

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The lanthanide complex, thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (TmDOTA-), has been investigated as an agent for MR thermometry in vivo. The chemical shifts of the TmDOTA- protons were highly sensitive to temperature at a clinically relevant field strength, yet insensitive to pH and the presence of Ca2+. Given the excellent stability of lanthanide-DOTA complexes and high thermal sensitivity, TmDOTA- is expected to be a good candidate for MR thermometry in vivo.

Original languageEnglish (US)
Pages (from-to)101-106
Number of pages6
JournalJournal of Magnetic Resonance
Volume151
Issue number1
DOIs
StatePublished - 2001

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Thermometry
temperature measurement
Lanthanoid Series Elements
thulium
probes
Thulium
chemical equilibrium
field strength
Chemical shift
acids
protons
Protons
Hot Temperature
Temperature
temperature
thulium-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate

ASJC Scopus subject areas

  • Molecular Biology
  • Physical and Theoretical Chemistry
  • Spectroscopy
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

Cite this

TmDOTA- : A sensitive probe for MR thermometry in vivo. / Zuo, Chun S.; Mahmood, Ashfaq; Sherry, A. Dean.

In: Journal of Magnetic Resonance, Vol. 151, No. 1, 2001, p. 101-106.

Research output: Contribution to journalArticle

Zuo, Chun S. ; Mahmood, Ashfaq ; Sherry, A. Dean. / TmDOTA- : A sensitive probe for MR thermometry in vivo. In: Journal of Magnetic Resonance. 2001 ; Vol. 151, No. 1. pp. 101-106.
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