Toll-like receptor signaling pathways - Therapeutic opportunities

Chandra Mohan, Jiankun Zhu

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

Toll-like receptors (TLRs) are transmembrane proteins acting mainly as sensors of microbial components. Triggering TLRs results in increased expression of multiple inflammatory genes, which then play a protective role against infection. However, aberrant activation of TLR signaling has a significant impact on the onset of cancer, allergy, sepsis and autoimmunity. Various adaptor proteins, including MyD88, IRAKs, TIRAP, TRIF, and TRAM, are involved in specific TLR signaling pathways. This article reviews the role of these molecules in TLR signaling, and discusses the impact of this pathway on various disease scenarios. Given their important role in infectious and non-infectious disease settings, TLRs and their signaling pathways emerge as attractive targets for therapeutics.

Original languageEnglish (US)
Article number781235
JournalMediators of Inflammation
Volume2010
DOIs
StatePublished - 2010

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Toll-Like Receptors
Therapeutics
Myeloid Differentiation Factor 88
Autoimmunity
Sepsis
Hypersensitivity
Infection
Genes
Neoplasms
Proteins

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Cite this

Toll-like receptor signaling pathways - Therapeutic opportunities. / Mohan, Chandra; Zhu, Jiankun.

In: Mediators of Inflammation, Vol. 2010, 781235, 2010.

Research output: Contribution to journalArticle

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