Remodeling of chromatin, distinct from activation of NF-κB, is a newly identified function of Toll-like receptors in mammals. In Drosophila, Toll receptors play a role in development as well as immunity; yet in mammals, they have an immunological role only. Further clues to the evolutionary development of the Toll receptors are emerging.
ASJC Scopus subject areas
- Immunology and Allergy