Total synthesis and absolute configuration of the novel microtubule-stabilizing agent peloruside A

Xibin Liao; Yusheng Wu; Jef K. De Brabander

doi:10.1002/anie.200351145

Total synthesis and absolute configuration of the novel microtubule-stabilizing agent peloruside A

Xibin Liao, Yusheng Wu, Jef K. De Brabander

Research output: Contribution to journal › Article › peer-review

128 Scopus citations

Abstract

A unique configuration-dependent mechanistic switch, observed when epimeric seco-acids are subjected to typical Mitsunobu lactonization conditions, is just one of the many unexpected, yet insightful surprises of a synthetic adventure culminating in the first enantioselective total synthesis of the novel microtubule-stabilizing natural product peloruside A (1).

Original language	English (US)
Pages (from-to)	1648-1652
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	42
Issue number	14
DOIs	https://doi.org/10.1002/anie.200351145
State	Published - Apr 11 2003

Keywords

Antitumor agents
Configuration determination
Cyclization
Natural products
Total synthesis

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.200351145

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abstract = "A unique configuration-dependent mechanistic switch, observed when epimeric seco-acids are subjected to typical Mitsunobu lactonization conditions, is just one of the many unexpected, yet insightful surprises of a synthetic adventure culminating in the first enantioselective total synthesis of the novel microtubule-stabilizing natural product peloruside A (1).",

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KW - Cyclization

KW - Natural products

KW - Total synthesis

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Total synthesis and absolute configuration of the novel microtubule-stabilizing agent peloruside A

Abstract

Keywords

ASJC Scopus subject areas

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