Total synthesis and absolute configuration of the novel microtubule-stabilizing agent peloruside A

Xibin Liao, Yusheng Wu, Jef K. De Brabander

Research output: Contribution to journalArticle

117 Scopus citations


A unique configuration-dependent mechanistic switch, observed when epimeric seco-acids are subjected to typical Mitsunobu lactonization conditions, is just one of the many unexpected, yet insightful surprises of a synthetic adventure culminating in the first enantioselective total synthesis of the novel microtubule-stabilizing natural product peloruside A (1).

Original languageEnglish (US)
Pages (from-to)1648-1652
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number14
StatePublished - Apr 11 2003



  • Antitumor agents
  • Configuration determination
  • Cyclization
  • Natural products
  • Total synthesis

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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