Total synthesis and biological evaluation of apicularen A and synthetic analogs

Ashoke Bhattacharjee, Olga R. Seguil, Jef K. De Brabander

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

The first total synthesis of the potent cytostatic agent apicularen A is described along with the synthesis of the corresponding C11-epimers and side chain modified congeners. Growth inhibition experiments with the human melanoma cancer cell line SK-MEL-5 revealed an important role for the unusual N-acyl enamide side chain.

Original languageEnglish (US)
Pages (from-to)1217-1220
Number of pages4
JournalTetrahedron Letters
Volume42
Issue number7
DOIs
StatePublished - Feb 12 2001

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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