Total synthesis of 5(S),12(S)- and 5(S),12(R)-dihydroxyeicosa-6(Z),8(E),14(Z)-trienoic acids, metabolites of leukotriene B4

Pendri Yadagiri, Sun Lumin, J. R. Falck, Armando Karara, Jorge Capdevila

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The recently identified dihydro-leukotriene B4 metabolite 1 and its C(12)-epi analogue 2 were prepared by Wittig coupling of segments derived from 2-deoxy-D-ribose and L-glutamic acid.

Original languageEnglish (US)
Pages (from-to)429-432
Number of pages4
JournalTetrahedron Letters
Volume30
Issue number4
DOIs
StatePublished - 1989

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Leukotriene B4
Ribose
Metabolites
Glutamic Acid
Acids

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Total synthesis of 5(S),12(S)- and 5(S),12(R)-dihydroxyeicosa-6(Z),8(E),14(Z)-trienoic acids, metabolites of leukotriene B4 . / Yadagiri, Pendri; Lumin, Sun; Falck, J. R.; Karara, Armando; Capdevila, Jorge.

In: Tetrahedron Letters, Vol. 30, No. 4, 1989, p. 429-432.

Research output: Contribution to journalArticle

Yadagiri, Pendri ; Lumin, Sun ; Falck, J. R. ; Karara, Armando ; Capdevila, Jorge. / Total synthesis of 5(S),12(S)- and 5(S),12(R)-dihydroxyeicosa-6(Z),8(E),14(Z)-trienoic acids, metabolites of leukotriene B4 In: Tetrahedron Letters. 1989 ; Vol. 30, No. 4. pp. 429-432.
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