Total synthesis of 5(S),12(S)- and 5(S),12(R)-dihydroxyeicosa-6(Z),8(E),14(Z)-trienoic acids, metabolites of leukotriene B4

Pendri Yadagiri, Sun Lumin, J. R. Falck, Armando Karara, Jorge Capdevila

Research output: Contribution to journalArticle

14 Scopus citations


The recently identified dihydro-leukotriene B4 metabolite 1 and its C(12)-epi analogue 2 were prepared by Wittig coupling of segments derived from 2-deoxy-D-ribose and L-glutamic acid.

Original languageEnglish (US)
Pages (from-to)429-432
Number of pages4
JournalTetrahedron Letters
Issue number4
StatePublished - 1989


ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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