Total synthesis of 5(S),12(S)- and 5(S),12(R)-dihydroxyeicosa-6(Z),8(E),14(Z)-trienoic acids, metabolites of leukotriene B4

Pendri Yadagiri; Sun Lumin; J. R. Falck; Armando Karara; Jorge Capdevila

doi:10.1016/S0040-4039(00)95219-5

Total synthesis of 5(S),12(S)- and 5(S),12(R)-dihydroxyeicosa-6(Z),8(E),14(Z)-trienoic acids, metabolites of leukotriene B₄

Pendri Yadagiri, Sun Lumin, J. R. Falck, Armando Karara, Jorge Capdevila

Biochemistry

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The recently identified dihydro-leukotriene B₄ metabolite 1 and its C(12)-epi analogue 2 were prepared by Wittig coupling of segments derived from 2-deoxy-D-ribose and L-glutamic acid.

Original language	English (US)
Pages (from-to)	429-432
Number of pages	4
Journal	Tetrahedron Letters
Volume	30
Issue number	4
DOIs	https://doi.org/10.1016/S0040-4039(00)95219-5
State	Published - 1989

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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title = "Total synthesis of 5(S),12(S)- and 5(S),12(R)-dihydroxyeicosa-6(Z),8(E),14(Z)-trienoic acids, metabolites of leukotriene B4",

abstract = "The recently identified dihydro-leukotriene B4 metabolite 1 and its C(12)-epi analogue 2 were prepared by Wittig coupling of segments derived from 2-deoxy-D-ribose and L-glutamic acid.",

author = "Pendri Yadagiri and Sun Lumin and Falck, {J. R.} and Armando Karara and Jorge Capdevila",

year = "1989",

doi = "10.1016/S0040-4039(00)95219-5",

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pages = "429--432",

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T1 - Total synthesis of 5(S),12(S)- and 5(S),12(R)-dihydroxyeicosa-6(Z),8(E),14(Z)-trienoic acids, metabolites of leukotriene B4

AU - Yadagiri, Pendri

AU - Lumin, Sun

AU - Falck, J. R.

AU - Karara, Armando

AU - Capdevila, Jorge

PY - 1989

Y1 - 1989

N2 - The recently identified dihydro-leukotriene B4 metabolite 1 and its C(12)-epi analogue 2 were prepared by Wittig coupling of segments derived from 2-deoxy-D-ribose and L-glutamic acid.

AB - The recently identified dihydro-leukotriene B4 metabolite 1 and its C(12)-epi analogue 2 were prepared by Wittig coupling of segments derived from 2-deoxy-D-ribose and L-glutamic acid.

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U2 - 10.1016/S0040-4039(00)95219-5

DO - 10.1016/S0040-4039(00)95219-5

M3 - Article

AN - SCOPUS:0024490728

SN - 0040-4039

VL - 30

SP - 429

EP - 432

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 4

ER -

Total synthesis of 5(S),12(S)- and 5(S),12(R)-dihydroxyeicosa-6(Z),8(E),14(Z)-trienoic acids, metabolites of leukotriene B₄

Abstract

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