Total synthesis of 5(S),20- and 15(S),20-dihydroxyeicosatetraenoic acid and 5(S),6(R)-epoxy-20-hydroxy- and 14(R),15(S)-epoxy-20-hydroxyeicosatreinoic acid

Sun Lumin, Pendri Yadagiri, J R Falck, Jorge Capdevila, Paul Mosset, René Grée

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Aldehyde (1), derived from dimethyl L-malate, was exploited in a stereocontrolled total synthesis of the ω-hydroxylated eicosanoid metabolites 5(S),20- and 15(S),20-dihydroxyeicosatetraenoic acid as well as 5(S),6(R)-epoxy-20-hydroxy- and 14(R),15(S)-epoxy-20-hydroxyeicosatrienoic acid.

Original languageEnglish (US)
Pages (from-to)389-390
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number5
DOIs
StatePublished - 1987

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Acids
Eicosanoids
Metabolites
Aldehydes
malic acid

ASJC Scopus subject areas

  • Molecular Medicine

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Total synthesis of 5(S),20- and 15(S),20-dihydroxyeicosatetraenoic acid and 5(S),6(R)-epoxy-20-hydroxy- and 14(R),15(S)-epoxy-20-hydroxyeicosatreinoic acid. / Lumin, Sun; Yadagiri, Pendri; Falck, J R; Capdevila, Jorge; Mosset, Paul; Grée, René.

In: Journal of the Chemical Society, Chemical Communications, No. 5, 1987, p. 389-390.

Research output: Contribution to journalArticle

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abstract = "Aldehyde (1), derived from dimethyl L-malate, was exploited in a stereocontrolled total synthesis of the ω-hydroxylated eicosanoid metabolites 5(S),20- and 15(S),20-dihydroxyeicosatetraenoic acid as well as 5(S),6(R)-epoxy-20-hydroxy- and 14(R),15(S)-epoxy-20-hydroxyeicosatrienoic acid.",
author = "Sun Lumin and Pendri Yadagiri and Falck, {J R} and Jorge Capdevila and Paul Mosset and Ren{\'e} Gr{\'e}e",
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AU - Lumin, Sun

AU - Yadagiri, Pendri

AU - Falck, J R

AU - Capdevila, Jorge

AU - Mosset, Paul

AU - Grée, René

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