Total synthesis of 5(S),20- and 15(S),20-dihydroxyeicosatetraenoic acid and 5(S),6(R)-epoxy-20-hydroxy- and 14(R),15(S)-epoxy-20-hydroxyeicosatreinoic acid

Sun Lumin, Pendri Yadagiri, J R Falck, Jorge Capdevila, Paul Mosset, René Grée

Research output: Contribution to journalArticlepeer-review

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Abstract

Aldehyde (1), derived from dimethyl L-malate, was exploited in a stereocontrolled total synthesis of the ω-hydroxylated eicosanoid metabolites 5(S),20- and 15(S),20-dihydroxyeicosatetraenoic acid as well as 5(S),6(R)-epoxy-20-hydroxy- and 14(R),15(S)-epoxy-20-hydroxyeicosatrienoic acid.

Original languageEnglish (US)
Pages (from-to)389-390
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number5
DOIs
StatePublished - Dec 1 1987

ASJC Scopus subject areas

  • Molecular Medicine

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