Abstract
3(S)-Hydroxy-Leukotriene B4 (1a), its 3(R)-epimer 1b, and a 14,15-acetylenic analogue were efficiently prepared via chelation-controlled reduction of ketone 12, obtained by acetylide addition to chiral β-hydroxylactones 7/9.
Original language | English (US) |
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Pages (from-to) | 1825-1828 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 35 |
Issue number | 12 |
DOIs | |
State | Published - Mar 21 1994 |
Keywords
- Rieke zinc
- Wittig
- chelation-controlled reduction
- eicosanoid
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry