Total synthesis of the ethanol inducible, proinflammatory autacoid 3(S)-hydroxy-leukotriene B4 (3-OH-LTB4) and analogues

Kamlesh Chauhan, Rama K. Bhatt, J R Falck, Jorge H. Capdevila

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

3(S)-Hydroxy-Leukotriene B4 (1a), its 3(R)-epimer 1b, and a 14,15-acetylenic analogue were efficiently prepared via chelation-controlled reduction of ketone 12, obtained by acetylide addition to chiral β-hydroxylactones 7/9.

Original languageEnglish (US)
Pages (from-to)1825-1828
Number of pages4
JournalTetrahedron Letters
Volume35
Issue number12
DOIs
StatePublished - Mar 21 1994

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Keywords

  • Rieke zinc
  • Wittig
  • chelation-controlled reduction
  • eicosanoid

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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