Touch preparation cytological evaluation of radical prostatectomy specimens

Margaret S Pearle, R. Oyasu, D. Hidvegi, D. Sutkowski, A. Rademaker, R. Cajulis, J. T. Grayhack, K. T. McVary

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The failure of current histological techniques to predict local failure and disease progression after radical prostatectomy is supported by substantial evidence. Moreover, the characterization of histological findings is hampered by the lack of uniform interpretation. We report a prospective study of 92 patients undergoing radical prostatectomy for clinical stages A and B prostate cancer in which the technique of touch preparation cytological analysis of surgical margins is compared to the standard histological approach. We evaluated 47 pathological stage B, 43 stage C and 2 stage D specimens. Specimens initially assigned to pathological stage B were upstaged to stage C on review by 1 blinded pathologist in 19 of 65 cases (29%). Overall, 15 of 47 histological stage B specimens (32%), 20 of 43 histological stage C specimens (47%) and 2 of 2 histological stage D specimens (100%) had malignant cells identified on the margins by touch preparation cytology. Postoperative mean followup of 7 months (range 0.4 to 26) revealed that 7 of 14 nonstage D cancer patients (50%) with elevated serum prostate specific antigen levels had positive cytology results, including 1 with histologically confirmed organ-confined disease. Among the stage C specimens cytology was more likely to be positive if there was concomitant seminal vesicle invasion. Correlation of this information with eventual patient course during the long term will be necessary to assess its role in patient management.

Original languageEnglish (US)
Pages (from-to)124-128
Number of pages5
JournalJournal of Urology
Volume152
Issue number1
StatePublished - 1994

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Touch
Prostatectomy
Cell Biology
Histological Techniques
Seminal Vesicles
Prostate-Specific Antigen
Disease Progression
Prostatic Neoplasms
Prospective Studies
Serum
Neoplasms

Keywords

  • cytological techniques
  • cytology
  • histology
  • prostatectomy
  • prostatic neoplasms

ASJC Scopus subject areas

  • Urology

Cite this

Pearle, M. S., Oyasu, R., Hidvegi, D., Sutkowski, D., Rademaker, A., Cajulis, R., ... McVary, K. T. (1994). Touch preparation cytological evaluation of radical prostatectomy specimens. Journal of Urology, 152(1), 124-128.

Touch preparation cytological evaluation of radical prostatectomy specimens. / Pearle, Margaret S; Oyasu, R.; Hidvegi, D.; Sutkowski, D.; Rademaker, A.; Cajulis, R.; Grayhack, J. T.; McVary, K. T.

In: Journal of Urology, Vol. 152, No. 1, 1994, p. 124-128.

Research output: Contribution to journalArticle

Pearle, MS, Oyasu, R, Hidvegi, D, Sutkowski, D, Rademaker, A, Cajulis, R, Grayhack, JT & McVary, KT 1994, 'Touch preparation cytological evaluation of radical prostatectomy specimens', Journal of Urology, vol. 152, no. 1, pp. 124-128.
Pearle MS, Oyasu R, Hidvegi D, Sutkowski D, Rademaker A, Cajulis R et al. Touch preparation cytological evaluation of radical prostatectomy specimens. Journal of Urology. 1994;152(1):124-128.
Pearle, Margaret S ; Oyasu, R. ; Hidvegi, D. ; Sutkowski, D. ; Rademaker, A. ; Cajulis, R. ; Grayhack, J. T. ; McVary, K. T. / Touch preparation cytological evaluation of radical prostatectomy specimens. In: Journal of Urology. 1994 ; Vol. 152, No. 1. pp. 124-128.
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