Toward synthetic transcription activators: Recruitment of transcription factors to DNA by a PNA-peptide chimera

Bo Liu, Ying Han, David R. Corey, Thomas Kodadek

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

A PNA-peptide chimera designed to mimic the biochemical function of transcription activators has been synthesized and characterized. The bis-PNA segment binds specifically to a DNA site while the 20-residue peptide is capable of binding to the transcription factors Gal11 and Gal80. The PNA-peptide chimera thus mimics one of the central functions of a native transcription activator, recruitment of transcription factors to a specific DNA site.

Original languageEnglish (US)
Pages (from-to)1838-1839
Number of pages2
JournalJournal of the American Chemical Society
Volume124
Issue number9
DOIs
StatePublished - Mar 6 2002

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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