Towards the Rational Design of Magnetic Resonance Imaging Contrast Agents: Isolation of the Two Coordination Isomers of Lanthanide DOTA-Type Complexes

Mark Woods, Zoltan Kovacs, Shanrong Zhang, A. Dean Sherry

Research output: Contribution to journalArticle

90 Scopus citations

Abstract

Controlling water exchange: Square antiprism (SAP; left) and twisted square antiprism (TSAP; right) coordination isomers of LnIII" DOTA-type complexes (DOTA= 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) may be isolated by choosing substituents on the ring and arms with identical chirality for the TSAP isomer, or with opposite chirality for the SAP isomer. The water exchange rates of the complexes differ by an order of magnitude.

Original languageEnglish (US)
Pages (from-to)5889-5892
Number of pages4
JournalAngewandte Chemie - International Edition
Volume42
Issue number47
DOIs
StatePublished - Dec 8 2003

Keywords

  • Coordination modes
  • Lanthanides
  • MRI contrast agents
  • Macrocyclic ligands

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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