Transcriptional activation by nuclear receptors

Mari Luz Acevedo, W. Lee Kraus

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations

Abstract

Transcriptional activation by nuclear receptors (NRs) involves the recruitment of distinct classes of co-activators and other transcription-related factors to target promoters in the chromatin environment of the nucleus. Chromatin has a general repressive effect on transcription, but also provides opportunities for NRs to regulate transcription by directing specific patterns of chromatin remodelling and histone modification. Ultimately, the transcription of hormone-regulated genes by NRs is critically dependent on co-ordinated physical and functional interactions among the receptors, chromatin, co-activators with chromatin-, histone- and factor-modifying activities, and the RNA polymerase II transcriptional machinery. In addition, several mechanisms exist to terminate or attenuate NR-dependent signalling, including modification, recycling, subcellular redistribution and degradation of the receptors or their associated cofactors. The complexity of NR-dependent transcription provides multiple targets for regulatory inputs, thus allowing each hormone-responsive cell to direct its transcriptional output in a physiologically appropriate manner.

Original languageEnglish (US)
Pages (from-to)73-88
Number of pages16
JournalEssays in Biochemistry
Volume40
DOIs
StatePublished - Jan 1 2004

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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