Transcriptional and epigenetic regulation of oligodendrocyte development and myelination in the central nervous system

Ben Emery, Q. Richard Lu

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Central nervous system (CNS) myelination by oligodendrocytes (OLs) is a highly orchestrated process involving well-defined steps from specification of neural stem cells into proliferative OL precursors followed by terminal differentiation and subsequent maturation of these precursors into myelinating OLs. These specification and differentiation processes are mediated by profound global changes in gene expression, which are in turn subject to control by both extracellular signals and regulatory networks intrinsic to the OL lineage. Recently, basic transcriptional mechanisms that control OL differentiation and myelination have begun to be elucidated at the molecular level and on a genome scale. The interplay between transcription factors activated by differentiation-promoting signals and master regulators likely exerts a crucial role in controlling stage-specific progression of the OL lineage. In this review, we describe the current state of knowledge regarding the transcription factors and the epigenetic programs including histone methylation, acetylation, chromatin remodeling, micro-RNAs, and noncoding RNAs that regulate development of OLs and myelination.

Original languageEnglish (US)
JournalCold Spring Harbor perspectives in biology
Volume7
Issue number9
DOIs
StatePublished - Sep 1 2015

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Oligodendroglia
Neurology
Epigenomics
Transcription Factors
Central Nervous System
Specifications
Acetylation
Untranslated RNA
Methylation
Stem cells
MicroRNAs
Gene expression
Histones
Chromatin
Genes
Chromatin Assembly and Disassembly
Neural Stem Cells
Genome
Gene Expression

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Transcriptional and epigenetic regulation of oligodendrocyte development and myelination in the central nervous system. / Emery, Ben; Lu, Q. Richard.

In: Cold Spring Harbor perspectives in biology, Vol. 7, No. 9, 01.09.2015.

Research output: Contribution to journalArticle

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