Transforming growth factor-β receptor III downregulation in prostate cancer: Is inhibin B a tumor suppressor in prostate?

Nima Sharifi, Robert J. Lechleider, William L. Farrar

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The transforming growth factor-β (TGF-β) pathway plays dual roles in cancer, inhibiting epithelial cell growth under normal physiologic conditions, but promoting invasion and metastasis once growth inhibitory responses are lost. Two recent papers show that TGF-β receptor III is the most common TGF-β pathway component downregulated in prostate cancer. Here, we discuss the implications of these findings and what it may mean about the biology of this disease.

Original languageEnglish (US)
Pages (from-to)329-332
Number of pages4
JournalJournal of Molecular Endocrinology
Volume39
Issue number5-6
DOIs
StatePublished - Nov 2007

Fingerprint

Growth Factor Receptors
Transforming Growth Factors
Prostate
Prostatic Neoplasms
Down-Regulation
Neoplasms
Growth
Epithelial Cells
Neoplasm Metastasis
inhibin B

ASJC Scopus subject areas

  • Endocrinology

Cite this

Transforming growth factor-β receptor III downregulation in prostate cancer : Is inhibin B a tumor suppressor in prostate? / Sharifi, Nima; Lechleider, Robert J.; Farrar, William L.

In: Journal of Molecular Endocrinology, Vol. 39, No. 5-6, 11.2007, p. 329-332.

Research output: Contribution to journalArticle

Sharifi, Nima ; Lechleider, Robert J. ; Farrar, William L. / Transforming growth factor-β receptor III downregulation in prostate cancer : Is inhibin B a tumor suppressor in prostate?. In: Journal of Molecular Endocrinology. 2007 ; Vol. 39, No. 5-6. pp. 329-332.
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