Transfusing maternal blood to her newborn baby-irrespective of ABO mismatch

Sanjay Gokhale, Sankalp Gokhale

Research output: Contribution to journalArticle

Abstract

Background: Though blood transfusions are the common procedures in pediatric patients, transfusion reactions are rare in children. Though in adults, uncross-matched ABO group-specific blood is used in emergencies, there are no such reports in neonates and children. There are stray case reports about transfusing maternal blood for her baby and maternal blood is de facto compatible regardless of an ABO mismatch Objective: Confirming our previous hypothesis that maternal blood is compatible with her baby’s blood; and maternal blood can be used for transfusion in her newborn baby irrespective of ABO match/ mismatch. Design: Prospective interventional study. Setting and Participants: Fifty-one mother–baby pairs were recruited attending Pediatric Unit of our Community Hospital from 15 July 2013 to 13 July 2015. After obtaining consent from the parents, all the required lab tests were done. Since all lab reports were favourable; these babies qualified for transfusion of maternal blood. Interventions: Fifty-one sick newborns were transfused fresh whole maternal blood as a part of treatment; irrespective of mother–baby ABO match or mismatch. Results: All babies tolerated maternal blood well and showed significant and rapid improvement. Minimum period of observation was from a minimum of 32 to a maximum of 56 months. All the babies showed good growth and development. Conclusion: By observing a particular protocol and procedural techniques, mother’s blood may be used for transfusion in her own baby in neonatal period, irrespective of ABO mismatch. Significance: This is probably the largest series in world literature of 51 newborns being transfused maternal blood either ABO match or mismatch.

Original languageEnglish (US)
JournalJournal of Maternal-Fetal and Neonatal Medicine
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

Fingerprint

Mothers
Newborn Infant
Blood Transfusion
Pediatrics
Community Hospital
Growth and Development
Emergencies
Research Design
Parents
Observation
Prospective Studies

Keywords

  • ABO mismatch
  • bidirectional leakage of cells
  • bidirectional tolerance
  • mother as blood donor
  • transfusion compatibility

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

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abstract = "Background: Though blood transfusions are the common procedures in pediatric patients, transfusion reactions are rare in children. Though in adults, uncross-matched ABO group-specific blood is used in emergencies, there are no such reports in neonates and children. There are stray case reports about transfusing maternal blood for her baby and maternal blood is de facto compatible regardless of an ABO mismatch Objective: Confirming our previous hypothesis that maternal blood is compatible with her baby’s blood; and maternal blood can be used for transfusion in her newborn baby irrespective of ABO match/ mismatch. Design: Prospective interventional study. Setting and Participants: Fifty-one mother–baby pairs were recruited attending Pediatric Unit of our Community Hospital from 15 July 2013 to 13 July 2015. After obtaining consent from the parents, all the required lab tests were done. Since all lab reports were favourable; these babies qualified for transfusion of maternal blood. Interventions: Fifty-one sick newborns were transfused fresh whole maternal blood as a part of treatment; irrespective of mother–baby ABO match or mismatch. Results: All babies tolerated maternal blood well and showed significant and rapid improvement. Minimum period of observation was from a minimum of 32 to a maximum of 56 months. All the babies showed good growth and development. Conclusion: By observing a particular protocol and procedural techniques, mother’s blood may be used for transfusion in her own baby in neonatal period, irrespective of ABO mismatch. Significance: This is probably the largest series in world literature of 51 newborns being transfused maternal blood either ABO match or mismatch.",
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N2 - Background: Though blood transfusions are the common procedures in pediatric patients, transfusion reactions are rare in children. Though in adults, uncross-matched ABO group-specific blood is used in emergencies, there are no such reports in neonates and children. There are stray case reports about transfusing maternal blood for her baby and maternal blood is de facto compatible regardless of an ABO mismatch Objective: Confirming our previous hypothesis that maternal blood is compatible with her baby’s blood; and maternal blood can be used for transfusion in her newborn baby irrespective of ABO match/ mismatch. Design: Prospective interventional study. Setting and Participants: Fifty-one mother–baby pairs were recruited attending Pediatric Unit of our Community Hospital from 15 July 2013 to 13 July 2015. After obtaining consent from the parents, all the required lab tests were done. Since all lab reports were favourable; these babies qualified for transfusion of maternal blood. Interventions: Fifty-one sick newborns were transfused fresh whole maternal blood as a part of treatment; irrespective of mother–baby ABO match or mismatch. Results: All babies tolerated maternal blood well and showed significant and rapid improvement. Minimum period of observation was from a minimum of 32 to a maximum of 56 months. All the babies showed good growth and development. Conclusion: By observing a particular protocol and procedural techniques, mother’s blood may be used for transfusion in her own baby in neonatal period, irrespective of ABO mismatch. Significance: This is probably the largest series in world literature of 51 newborns being transfused maternal blood either ABO match or mismatch.

AB - Background: Though blood transfusions are the common procedures in pediatric patients, transfusion reactions are rare in children. Though in adults, uncross-matched ABO group-specific blood is used in emergencies, there are no such reports in neonates and children. There are stray case reports about transfusing maternal blood for her baby and maternal blood is de facto compatible regardless of an ABO mismatch Objective: Confirming our previous hypothesis that maternal blood is compatible with her baby’s blood; and maternal blood can be used for transfusion in her newborn baby irrespective of ABO match/ mismatch. Design: Prospective interventional study. Setting and Participants: Fifty-one mother–baby pairs were recruited attending Pediatric Unit of our Community Hospital from 15 July 2013 to 13 July 2015. After obtaining consent from the parents, all the required lab tests were done. Since all lab reports were favourable; these babies qualified for transfusion of maternal blood. Interventions: Fifty-one sick newborns were transfused fresh whole maternal blood as a part of treatment; irrespective of mother–baby ABO match or mismatch. Results: All babies tolerated maternal blood well and showed significant and rapid improvement. Minimum period of observation was from a minimum of 32 to a maximum of 56 months. All the babies showed good growth and development. Conclusion: By observing a particular protocol and procedural techniques, mother’s blood may be used for transfusion in her own baby in neonatal period, irrespective of ABO mismatch. Significance: This is probably the largest series in world literature of 51 newborns being transfused maternal blood either ABO match or mismatch.

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